Pantoate 4-dehydrogenase

From Wikipedia, the free encyclopedia

In enzymology, a pantoate 4-dehydrogenase (EC 1.1.1.106) is an enzyme that catalyzes the chemical reaction

(R)-pantoate + NAD⁺ (R)-4-dehydropantoate + NADH + H⁺

Thus, the two substrates of this enzyme are (R)-pantoate and NAD⁺, whereas its 3 products are (R)-4-dehydropantoate, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (R)-pantoate:NAD+ 4-oxidoreductase. Other names in common use include pantoate dehydrogenase, pantothenase, and D-pantoate:NAD+ 4-oxidoreductase. This enzyme participates in pantothenate and coa biosynthesis.

[edit] References

• IUBMB entry for 1.1.1.106
• BRENDA references for 1.1.1.106 (Recommended.)
• PubMed references for 1.1.1.106
• PubMed Central references for 1.1.1.106
• Google Scholar references for 1.1.1.106
• Goodhue CT, Snell EE (1966). "The bacterial degradation of pantothenic acid. 3. Enzymatic formation of aldopantoic acid". Biochemistry. 5: 403–8. doi:10.1021/bi00866a003. PMID 4287370. 

[edit] External links

The CAS registry number for this enzyme class is 37250-38-7.

• IUBMB entry for 1.1.1.106

• KEGG entry for 1.1.1.106

• BRENDA entry for 1.1.1.106

• NiceZyme view of 1.1.1.106

• EC2PDB: PDB structures for 1.1.1.106

• PRIAM entry for 1.1.1.106

• PUMA2 entry for 1.1.1.106

• IntEnz: Integrated Enzyme entry for 1.1.1.106

• MetaCyc entry for 1.1.1.106

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0050166: pantoate 4-dehydrogenase

• AMIGO entry for GO code 0050166: pantoate 4-dehydrogenase