Oxaloglycolate reductase (decarboxylating)

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In enzymology, an oxaloglycolate reductase (decarboxylating) (EC 1.1.1.92) is an enzyme that catalyzes the chemical reaction

D-glycerate + NAD(P)+ + CO₂ 2-hydroxy-3-oxosuccinate + NAD(P)H + 2 H⁺

The 4 substrates of this enzyme are D-glycerate, NAD⁺, NADP⁺, and CO₂, whereas its 4 products are 2-hydroxy-3-oxosuccinate, NADH, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is D-glycerate:NAD(P)+ oxidoreductase (carboxylating). This enzyme participates in glyoxylate and dicarboxylate metabolism.

[edit] References

• IUBMB entry for 1.1.1.92
• BRENDA references for 1.1.1.92 (Recommended.)
• PubMed references for 1.1.1.92
• PubMed Central references for 1.1.1.92
• Google Scholar references for 1.1.1.92
• Kohn LD, Jakoby WB (1968). "Tartaric acid metabolism. VI. Crystalline oxaloglycolate reductive decarboxylase". J. Biol. Chem. 243: 2486–93. PMID 4385076. 

[edit] External links

The CAS registry number for this enzyme class is 37250-28-5.

• IUBMB entry for 1.1.1.92

• KEGG entry for 1.1.1.92

• BRENDA entry for 1.1.1.92

• NiceZyme view of 1.1.1.92

• EC2PDB: PDB structures for 1.1.1.92

• PRIAM entry for 1.1.1.92

• PUMA2 entry for 1.1.1.92

• IntEnz: Integrated Enzyme entry for 1.1.1.92

• MetaCyc entry for 1.1.1.92

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047047: oxaloglycolate reductase (decarboxylating)

• AMIGO entry for GO code 0047047: oxaloglycolate reductase (decarboxylating)