Talk:Oncogene

From Wikipedia, the free encyclopedia

WikiProject Genetics This article is part of WikiProject Genetics, an attempt to build a comprehensive and detailed guide to genetics on Wikipedia. If you would like to participate, you can edit this page, or visit the project page to join the project and/or contribute to the discussion.
??? This article has not yet received a rating on the quality scale.
??? This article has not yet received an importance rating.
WikiProject Medicine This article is within the scope of WikiProject Medicine. Please visit the project page for details or ask questions at the doctor's mess.
Start This page has been rated as Start-Class on the quality assessment scale
Mid This article has been rated as Mid-importance on the importance assessment scale
This article was previously a Medicine Collaboration of the Week.
Molecular and Cellular Biology WikiProject
MCB Portal
This article is within the scope of the Molecular and Cellular Biology WikiProject. To participate, visit the WikiProject for more information. The WikiProject's current monthly collaboration is focused on improving Restriction enzyme.
Start This article has been rated as start-Class on the assessment scale.
High This article is on a subject of high-importance within molecular and cellular biology.

Article Grading: The article has been rated for quality and/or importance but has no comments yet. If appropriate, please review the article and then leave comments here to identify the strengths and weaknesses of the article and what work it will need.
To-do list for Oncogene: edit · history · watch · refresh

Here are some tasks you can do:

    Contents

    [edit] Style

    I'm beginning to feel that the number of links and random facts are interrupting the continuity of this article (e.g. is it really necessary to attribute the institution of Varums and Bishop? probably not). However, I do feel that the discussion on mutations is quite helpful for understanding of the topic. Brandon Tavshanjian

    [edit] microRNAs

    I am interested in making some rather substantial changes to this page, but thought it might be best to float some ideas here first.

    An example: the second (short) paragraph says:

    "New research indicates that small RNAs 21-25 nucleotides in length called miRNAs can control expression of these genes by downregulating them."

    This sentence is true, and there is a lot of interest to say about miRNAs and their involvement in cancer, but the above makes a generic statement about all genes that says nothing specific about oncogenes. On that basis, I would delete this paragraph.

    Comments?

    User:OncoAnalyst forgot to sign the above.

    Delete or rewrite. I would start by rewriting the above as "microRNAs can control expression of these genes by downregulating them." and add relevant sources. Also please rewrite the section on the microRNA page about cancer. Una Smith 04:35, 14 June 2007 (UTC)

    While I agree the connections between miRNAs and oncogenes are beginning to become intriguing, I really don't feel it belongs at the beginning of the article. I'm a big fan of the idea that these entries should be written in the "funnel" style, where we start with the most broad statements and then move on to specifics. In that light, miRNAs belong as a sub-heading later on in the article--placing them at the beginning is just confusing. It also doesn't necessarily contribute anything to the basic understanding of what an "oncogene" is.

    User:btavshan

    [edit] WikiProject class rating

    This article was automatically assessed because at least one WikiProject had rated the article as start, and the rating on other projects was brought up to start class. BetacommandBot 16:30, 10 November 2007 (UTC)

    [edit] Vandalism

    Someone has added extra material:

       "so they pretty much suck"
   "loss of bladder control"
   "a condition called proto-syntheticcanceritis"

    I don't want to remove it without discussion, hence this new section. -klode —Preceding unsigned comment added by 204.92.192.254 (talk) 05:31, 27 January 2008 (UTC)

    [edit] Conflicting statements in intro

    "Since the 1970s, dozens of oncogenes have been identified in cancer." and "Since the 1980s, dozens of oncogenes have been identified in human cancer." Cheers, Jack (talk) 14:29, 9 May 2008 (UTC)