Talk:Olanzapine

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Here's an important article that just came out in the NY Times http://www.nytimes.com/2006/12/18/business/18drug.html?hp&ex=1166504400&en=abbfa89f1f363c93&ei=5094&partner=homepage —Preceding unsigned comment added by 71.206.230.233 (talk)

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[edit] Picture

I have just uploaded a picture of a Zyprexa box: http://commons.wikimedia.org/wiki/Image:Zyprexa.PNG Feel free to insert into article if useful. --Stonyroad (talk) 10:03, 27 December 2007 (UTC)

[edit] edits by 67.82.232.151

A certain user 67.82.232.151 has a clear bias against the Eli Lilly Corporation, and has single-handedly created the current 'Legal' section. Since one guy with a grudge has had such a huge effect on this page, I’m adding a POV tag. I know nothing about the industry myself, but until someone can verify this information we should let people know what’s what.

Here are some of his edits to the Eli Lilly page:

Eli Lilly has been known to engage in withholding internal information on medications, including Prozac, Thimerosal and Zyprexa in order to downplay side effects and adverse reactions in order to boost profits. [1]

Consequently, many critics claim that the FDA approval of duloxetine for Major Depressive Disorder (MDD) and diabetic neuropathy is irresponsible and intellectually dishonest, and is a case illustration of the agency's failure to prevent harmful drugs from being marketed in the name of big profits. [2]

In one of the only three cases to ever go to trial for SSRI indication in suicide, Eli Lilly was caught corrupting the judicial process by making a deal with the plaintiff's attorney to throw the case, in part by not disclosing damaging evidence to the jury. [3]

Over the last decade, the company spent millions of dollars lobbying Congress in hopes of extending its patent on Prozac and some lawmakers even attempted to insert last-minute provisions to omnibus spending bills to grant the company’s wish. Generic drugmakers prevailed, handing Eli Lilly one of its few legislative losses in recent memory. The company, which favors Republicans over Democrats with its contributions… [4]

This same user also started the ‘Controversy’ statement on the Duloxetine page, containing the following outsourced and obviously biased statements:

In the 1980s, [Eli] Lilly waged a successful campaign to get fluoxetine, brand name Prozac, through the FDA even though not a single study submitted to the agency showed the drug to be effective for depression when taken alone. …not only targets serotonin, it also impacts another important neurochemical, norepinephrine. This flatly contradicts the ‘serotonin/good, norepinephrine/bad’ story that launched the SSRI revolution that [Eli] Lilly started with fluoxetine. [5]

He started a ‘Legal’ section on the Olanzapine page with this:

…documents given to The Times by a lawyer representing mentally ill patients, show that [Eli] Lilly executives kept important information from doctors about Zyprexa’s links to obesity and its tendency to raise blood sugar — both known risk factors for diabetes. [6]

He adds this unsourced statement to the SSRI Discontinuation Syndrome page:

Data obtained from 9 clinical trials assessing the efficacy and safety of duloxetine in the treatment of major depressive disorder (MDD) by Lilly Research found that patients with discontinuation-emergent adverse events (DEAEs) were reported by 44.3% of duloxetine patients… No follow up was published by [Eli] Lilly stating the duration of DEAE's longer than one week ultimately persisted for. [7]

--70.17.209.58 09:17, 22 March 2007 (UTC)

Neither section you tagged here as "totally disputed" was not completely written by user 67.82.232.151. Looking at the history shows the writing of those sections has been a collaberative effort. user 67.82.232.151 hasn't edited this article for over two months, many changes have been made since then. The sections are heavily referenced and that one former author's edits to other articles are not relivant to gauging its factual accuracy. I'm removing the "totally disputed" templates from those sections because their factual accuracy is not disputed. Neitherday 12:05, 22 March 2007 (UTC)
Q How do you see/find out the IP or the name of person who writes material on the front/title page?--Mark v1.0 00:08, 1 June 2007 (UTC)

[edit] POV

I removed the reference from Prozacspotlight. If the site cites a scientific study that has been published in a peer-reviewed journal, then inserting a direct reference may be much more helpful than a link to a news article. I admit I haven't taken the time to find the proper reference in Pubmed. The prozacspotlight.org site looks positively doubtful. JFW | T@lk 23:20, 17 Jun 2004 (UTC)

It seems to be gone from prozacspotlight... Found the old version here: [8]. The quote from the article made me scratch my head: "In 1999, for example, Eli Lilly received a paper on olanzapine, the best-selling antipsychotic drug in America. The study showed that, contrary to Lilly's hopes, olanzapine was not useful in the treatment of Parkinson's symptoms. " I have no idea why a dopamine antagonist would be useful in treating Parkinson's symptoms - perhaps for Levadopa induced psychosis. Regardless, I don't feel its an important reference and I'm glad its gone. ElBenevolente 00:45, 18 Jun 2004 (UTC)

Could somebody advise me where to insert information about lactation? It's a little discussed side effect by the manufacturer, but a fairly common one in females on this drug.

In a section called "side-effects". Please link to galactorrhea. JFW | T@lk

The NIH CATIE study is mentioned in the adverse events section, but the results with regards to effectiveness outcomes are not mentioned. It would be nice to work those into the article somehow. In fact, it would be nice to work into the articles for all the atypicals that were evaluated.--Anastasis00 16:11, 14 March 2006 (UTC)

Agree with explicit inclusion of CATIE (2 back-to-back papers: 1. McEvoy JP, Lieberman JA, Stroup TS, Davis SM, Meltzer HY, Rosenheck RA, et al. Effectiveness of clozapine versus olanzapine, quetiapine, and risperidone in patients with chronic schizophrenia who did not respond to prior atypical antipsychotic treatment.[see comment]. American Journal of Psychiatry 2006;163:600-10, and 2. Stroup TS, Lieberman JA, McEvoy JP, Swartz MS, Davis SM, Rosenheck RA, et al. Effectiveness of olanzapine, quetiapine, risperidone, and ziprasidone in patients with chronic schizophrenia following discontinuation of a previous atypical antipsychotic. American Journal of Psychiatry 2006;163:611-22). Equally important is the CUtLASS study (Jones PB, Barnes TRE, Davies L, Dunn G, Lloyd H, Hayhurst KP, et al. Randomized Controlled Trial of the Effect on Quality of Life of Second- vs First-Generation Antipsychotic Drugs in Schizophrenia: Cost Utility of the Latest Antipsychotic Drugs in Schizophrenia Study (CUtLASS 1). Archives of General Psychiatry 2006;63:1079-1087). Both studies were government funded and provide efficacy data challenging the widely advertised and hugely profitable superiority of atypical agents, including olanzapine, over older drugs. I wonder how to refer to these studies more elegantly. --Menkesd 03:26, 20 January 2007 (UTC)

I am not sure that this is the proper place to publish original case reports of adverse events associated with olanzapine, such as that inserted by 213.42.2.28 in edit dated March 17. If we want to reference case reports from the literature regarding suicidal ideation, altered sleep patterns, sedation, or other side effects I think that would be beneficial; however, I think comments such as "this drug was clearly and unambiguously to blame for the emotional horror" experienced during olanzapine treatment cannot be supported based on the information provided and are not appropriate in this setting. I am going to remove these additions to the adverse event section at this time.--Anastasis00 04:48, 29 March 2006 (UTC)

[edit] Zyprexa diabetes link

I took zyprexa starting in 1996 the year the FDA approved it, which was ineffective for my condition and gave me diabetes.

Zyprexa is the product name for Olanzapine,it is Lilly's top selling drug.It was approved by the FDA in 1996 ,an 'atypical' antipsychotic a newer class of drugs without the motor side effects of the older Thorazine.Zyprexa has been linked to causing diabetes and pancreatitis.

Zyprexa, which is used for the treatment of psychiatric disorders, such as schizophrenia and bipolar disorder, accounted for 32% of Eli Lilly's $14.6 billion revenue last year.

Did you know that Lilly made nearly $3 billion last year on diabetic meds, Actos,Humulin and Byetta?

Yes! They sell a drug that can cause diabetes and then turn a profit on the drugs that treat the condition that they may have caused in the first place! I was prescribed Zyprexa from 1996 until 2000. In early 2000 i was shocked to have an A1C test result of 13.9 (normal is 4-6) I have no history of diabetes in my family.

All the psychiatrist I've interviewed and the information on line presents zyprexa as a worse offender than the other Atypicals such as seroquel.My doctor has stopped prescribing zyprexa altogether.

The PDR classifies zyprexa as 'severe' for causing weight gain and diabetes and seroquel as 'moderate'.

Of course the 50 year old Thorazine didn't cause diabetes and is many times cheaper but it could cause tardive dyskinesia.

Where Eli Lilly's negligence comes in,is their KNOWING and not informing consumers (black box warning) until the FDA demanded it.

Lilly's incentive not to readily disclose is they had billions coming in from state medicaid scripts.

Daniel Haszard http://www.zyprexa-victims.com

Zyprexa and diabetes? I use zyprexa and have used other anti-psychotics in the past (risperdal, haldol). I have found that zyprexa is the medicine which has the least side effects for me. Especially haldol was pure hell, risperdal made me shiver. So i am basically happy with zyprexa, but how great is the risk for diabetes. Should I be worried? When I was admitted to a psychiatric hospital and received zyprexa I did have some diabetic like symptoms. (Thirst, feeling dehydrated etc.), but I have not had similar complaints since and I have been taking it on and off for 3 years now.

I suspect the diabetes risk is mainly due to weight gain. But then again.. there have been no real studies about the onset of diabetes due to the antipsychotic. --Moop stick | (Talk) 16:01, 6 August 2006 (UTC)

Christian: I've used Risperdal first to treat my psychosis/bipolar disorder and I experienced massive side-effects. I couldn't sleep, weight gain, zombie-tiredness, panics and more. When I changed to Zyprexa it was really nice cause I gave almost no side-effects after a first period in which I had thirst and dehydration. Zyprexa is really good to me can't say otherwise but I know it can cause diabetes in people, I was informed about this when I started so its real use to eat low-GI-food. Avoid sugars. Zyprexa is my less bad choice of medicine to survive

I've had great results with Zyprexa and no diabetes after a year on it. I have, however, gained 40 pounds and will be discussing a switch with my Dr. I would consider Zyprexa Zydis which supposedly does not cause weight gain or Geodon which does not as well. I'm afraid the diabetes may result from excessive weight gain AND I seem to crave carbs (sugars).

[edit] Aphilia

I removed the sentence on Aphilia for two reasons 1) it is not a recognized psychiatric symptom or diagnosis, and 2) olanzapine has no indication in treating it. Dr.JonathanCrane 03:50, 22 August 2006 (UTC)

[edit] "Judge Weinstein"

Judge Weinstein needs to be identified> I'd do it myself if I knew. Has essential information been suppressed here? --Wetman 09:56, 18 December 2006 (UTC)

[edit] I actually eat Zyprexa

I think most psychiatric patients (myself included) wants to be rid of mecication. Next, I think you guys got it all wrong. I myself have been chased by demons, heard the evil whispering of trees and the general "mind-read", and I also gained the "mandatory" 22-23 pounds, so I am now no longer underweight as I was before (I didn't feel the need to eat, it was a waste of time and inefficient). Now I am overweight, that's true, but I'd rather be "normal" eating my meds, without people reading my mind and the general deathwish. Next up, a big surprise, Diabetes (type 2) don't even need medication, just a regular ingestion of food. What did you imagine? I mean come on, a medication without sideeffects, please try to focus on BOTH sides. And if it was as toxic (like this single-sided article clearly suggests) I'd be long dead! --Eternalsleeper (talk) 07:19, 3 March 2008 (UTC)

Oh yes, and before you start a rant "Ooooh we have someone from Lilly in here!!!", please think twice, maybe consider a long chat with a shrink! Got to go and eat my beloved Zyprexa.

--ChrKrabbe 21:40, 10 January 2007 (UTC)

[edit] weight gain statistics?

was looking into the weight gain statistics her on this page, and haven't been able to find a verifiable source for 90% of users experience weight gain. only one article i've been able to access has any metrics as to the amount of weight gained, which still makes no mention of percentages of samples that gained weight. if someone could enlighten me as to where we are getting this numbers i would appreciate it, otherwise feel that the information is innacurate and should be removed. Acee2bee 13:12, 5 June 2007 (UTC)

Yeah, I'd never heard 90% but there is alot of disagreement, though all would agree it is significant. My bet would be to leave as "significant" unitl some consensus on numbers occurs.cheers, Cas Liber | talk | contribs 14:13, 5 June 2007 (UTC)
I know that Wikipedia is against original research but I know a psychiatrist who is vehemently against putting people on Zyprexa due to the massive amounts of weight the patients gain. I personally know someone who went 160 to 220 lbs on this horrid medication.
--Eternalsleeper (talk) 07:19, 3 March 2008 (UTC)

[edit] Gout?

Someone added to the list of side effects *Gout and similar symptoms. But gout is not a symptom, and gout is caused by hyperuricemia, which is not mentioned in this article. I have removed the suspect text. The claim that this drug causes gout needs supporting evidence. --Una Smith 18:26, 27 August 2007 (UTC)