Norspermidine
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| Norspermidine | |
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| IUPAC name | N-(3-aminopropyl)propane-1,3-diamine |
| Other names | 3,3'-diaminodipropylamine bis-(3-aminopropyl)amine dipropylenetriamine norspermidine Caldine |
| Identifiers | |
| CAS number | [56-18-8] |
| SMILES | C(CN)CNCCCN |
| Properties | |
| Molecular formula | C6H17N3 |
| Molar mass | 131.22 g/mol |
| Appearance | Clear, colorless liquid |
| Density | 0.9380 g/cm³, liquid |
| Melting point |
−14 °C (7 °F) |
| Boiling point |
235 °C (455 °F) (at 760 mmHg) |
| Hazards | |
| MSDS | Norspermidine MSDS |
| Flash point | 118 °C (244.4 °F) |
| Autoignition temperature |
280 °C (536 °F) |
| Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox disclaimer and references |
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Norspermidine is a polyamine of similar structure to the more common spermidine. While norspermidine has been found to occur naturally in some species of plants[1][2], bacteria[3], and algae[4], it is not known to be a natural product in humans as spermidine is.
Norspermidine is being researched for its use as an antitumor medicine in cancer treatment[5][6].
[edit] References
- ^ Rodriguez-Garay, B et al (1989). "Detection of Norspermidine and Norspermine in Medicago sativa L. (Alfalfa)". Plant Physiology 89: 525–529. ISSN: 0032-0889.
- ^ Hamana, K et al (1998). "Unusual polyamines in aquatic plants: the occurrence of homospermidine, norspermidine, thermospermine, norspermine, aminopropylhomospermidine, bis(aminopropyl)ethanediamine, and methylspermidine". Can. J. Bot. 76 (1): 130–133. doi:.
- ^ Yamamoto, S et al (Apr. 27, 1979). "Occurrence of norspermidine in some species of genera Vibrio and Beneckea". Biochem Biophys Res Commun. 87 (4): 1102–1108. doi:. PMID 313792.
- ^ Hamana, K; Matsuzaki, S (1982). "Widespread Occurrence of Norspermidine and Norspermine in Eukaryotic Algae". J. Biochem 91 (4): 1321–1328. ISSN: 0021-924X.
- ^ Prakash, NJ et al (1988). "Antitumor activity of norspermidine, a structural homologue of the natural polyamine spermidine". Anticancer Res. 8 (4): 563–568. PMID 3140710.
- ^ Sunkara, PS et al (1988). "Mechanism of antitumor activity of norspermidine, a structural homologue of spermidine". Adv Exp Med Biol. 250: 707–716. PMID 3255245.
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