Nitroquinoline-N-oxide reductase

From Wikipedia, the free encyclopedia

In enzymology, a nitroquinoline-N-oxide reductase (EC 1.7.1.9) is an enzyme that catalyzes the chemical reaction

4-(hydroxyamino)quinoline N-oxide + 2 NAD(P)+ + H₂O 4-nitroquinoline N-oxide + 2 NAD(P)H + 2 H⁺

The 4 substrates of this enzyme are 4-hydroxyaminoquinoline N-oxide, NAD⁺, NADP⁺, and H₂O, whereas its 4 products are 4-nitroquinoline N-oxide, NADH, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on other nitrogenous compounds as donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 4-(hydroxyamino)quinoline N-oxide:NADP+ oxidoreductase. Other names in common use include 4-nitroquinoline 1-oxide reductase, 4NQO reductase, and NAD(P)H2:4-nitroquinoline-N-oxide oxidoreductase.

[edit] References

• IUBMB entry for 1.7.1.9
• BRENDA references for 1.7.1.9 (Recommended.)
• PubMed references for 1.7.1.9
• PubMed Central references for 1.7.1.9
• Google Scholar references for 1.7.1.9
• Toriyama N (1965). "[Metabolism of quinoline derivatives. On the reducing enzyme of 4-nitroquinoline-N-oxide]". Nichidai Igaku Zasshi 24: 423–432. 
• Stanley JS, York JL, Benson AM (1992). "Nitroreductases and glutathione transferases that act on 4-nitroquinoline 1-oxide and their differential induction by butylated hydroxyanisole in mice". Cancer. Res. 52: 58–63. PMID 1370076. 

[edit] External links

The CAS registry number for this enzyme class is 37256-35-2.

• IUBMB entry for 1.7.1.9

• KEGG entry for 1.7.1.9

• BRENDA entry for 1.7.1.9

• NiceZyme view of 1.7.1.9

• EC2PDB: PDB structures for 1.7.1.9

• PRIAM entry for 1.7.1.9

• PUMA2 entry for 1.7.1.9

• IntEnz: Integrated Enzyme entry for 1.7.1.9

• MetaCyc entry for 1.7.1.9

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0050465: nitroquinoline-N-oxide reductase

• AMIGO entry for GO code 0050465: nitroquinoline-N-oxide reductase