NAD(P)H oxidase

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In enzymology, a NAD(P)H oxidase (EC 1.6.3.1) is an enzyme that catalyzes the chemical reaction

NAD(P)H + H⁺ + O₂ $\rightleftharpoons$ NAD(P)+ + H₂O₂

The 4 substrates of this enzyme are NADH, NADPH, H⁺, and O₂, whereas its 3 products are NAD⁺, NADP⁺, and H₂O₂.

This enzyme belongs to the family of oxidoreductases, specifically those acting on NADH or NADPH with oxygen as acceptor. The systematic name of this enzyme class is NAD(P)H:oxygen oxidoreductase. Other names in common use include THOX2, ThOX, dual oxidase, p138tox, thyroid NADPH oxidase, thyroid oxidase, thyroid oxidase 2, and NADPH oxidase.

[edit] References

IUBMB entry for 1.6.3.1
BRENDA references for 1.6.3.1 (Recommended.)
PubMed references for 1.6.3.1
PubMed Central references for 1.6.3.1
Google Scholar references for 1.6.3.1
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De Deken X, Wang D, Dumont JE, Miot F (2002). "Characterization of ThOX proteins as components of the thyroid H(2)O(2)-generating system". Exp. Cell. Res. 273: 187–96. doi:10.1006/excr.2001.5444. PMID 11822874.
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Dupuy C, Ohayon R, Valent A, Noel-Hudson MS, Deme D, Virion A (1999). "Purification of a novel flavoprotein involved in the thyroid NADPH oxidase. Cloning of the porcine and human cdnas". J. Biol. Chem. 274: 37265–9. doi:10.1074/jbc.274.52.37265. PMID 10601291.
Carvalho D, Dupuy C, Virion A (1999). "Biochemical characterization of a Ca2+/NAD(P)H-dependent H2O2 generator in human thyroid tissue". Biochimie. 81: 373–80. doi:10.1016/S0300-9084(99)80084-4. PMID 10401672.
Dupuy C, Virion A, Ohayon R, Kaniewski J, Deme D, Pommier J (1991). "Mechanism of hydrogen peroxide formation catalyzed by NADPH oxidase in thyroid plasma membrane". J. Biol. Chem. 266: 3739–43. PMID 1995628.