mRNA (2'-O-methyladenosine-N6-)-methyltransferase

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In enzymology, a mRNA (2'-O-methyladenosine-N6-)-methyltransferase (EC 2.1.1.62) is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine + m₇G(5')pppAm S-adenosyl-L-homocysteine + m₇G(5')pppm₆Am (mRNA containing an N₆,2'-O-dimethyladenosine cap)

Thus, the two substrates of this enzyme are S-adenosyl methionine and m7G(5')pppAm, whereas its two products are S-adenosylhomocysteine and m7G(5')pppm6Am (mRNA containing an N6,2'-O-dimethyladenosine cap).

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:mRNA (2'-O-methyladenosine-N6-)-methyltransferase. Other names in common use include messenger ribonucleate 2'-O-methyladenosine NG-methyltransferase, S-adenosyl-L-methionine:mRNA, and (2'-O-methyladenosine-6-N-)-methyltransferase.

[edit] References

• IUBMB entry for 2.1.1.62
• BRENDA references for 2.1.1.62 (Recommended.)
• PubMed references for 2.1.1.62
• PubMed Central references for 2.1.1.62
• Google Scholar references for 2.1.1.62
• Keith JM, Ensinger MJ, Mose B (1978). "HeLa cell RNA (2'-O-methyladenosine-N6-)-methyltransferase specific for the capped 5'-end of messenger RNA". J. Biol. Chem. 253: 5033–9. PMID 670176. 

[edit] External links

The CAS registry number for this enzyme class is 68009-87-0.

• IUBMB entry for 2.1.1.62

• KEGG entry for 2.1.1.62

• BRENDA entry for 2.1.1.62

• NiceZyme view of 2.1.1.62

• EC2PDB: PDB structures for 2.1.1.62

• PRIAM entry for 2.1.1.62

• PUMA2 entry for 2.1.1.62

• IntEnz: Integrated Enzyme entry for 2.1.1.62

• MetaCyc entry for 2.1.1.62

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0016422: mRNA (2'-O-methyladenosine-N6-)-methyltransferase

• AMIGO entry for GO code 0016422: mRNA (2'-O-methyladenosine-N6-)-methyltransferase