Morphine 6-dehydrogenase

From Wikipedia, the free encyclopedia

In enzymology, a morphine 6-dehydrogenase (EC 1.1.1.218) is an enzyme that catalyzes the chemical reaction

morphine + NAD(P)+ morphinone + NAD(P)H + H⁺

The 3 substrates of this enzyme are morphine, NAD⁺, and NADP⁺, whereas its 4 products are morphinone, NADH, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is morphine:NAD(P)+ 6-oxidoreductase. Other names in common use include naloxone reductase, and reductase, naloxone. This enzyme participates in alkaloid biosynthesis i. This enzyme has at least one effector, Mercaptoethanol.

[edit] References

• IUBMB entry for 1.1.1.218
• BRENDA references for 1.1.1.218 (Recommended.)
• PubMed references for 1.1.1.218
• PubMed Central references for 1.1.1.218
• Google Scholar references for 1.1.1.218
• Yamano S, Kageura E, Ishida T, Toki S (1985). "Purification and characterization of guinea pig liver morphine 6-dehydrogenase". J. Biol. Chem. 260: 5259–64. PMID 2580834. 
• Yamano S, Nishida F, Toki S (1986). "Guinea-pig liver morphine 6-dehydrogenase as a naloxone reductase". Biochem. Pharmacol. 35: 4321–6. doi:10.1016/0006-2952(86)90712-4. PMID 3539118. 

[edit] External links

The CAS registry number for this enzyme class is 97002-71-6.

• IUBMB entry for 1.1.1.218

• KEGG entry for 1.1.1.218

• BRENDA entry for 1.1.1.218

• NiceZyme view of 1.1.1.218

• EC2PDB: PDB structures for 1.1.1.218

• PRIAM entry for 1.1.1.218

• PUMA2 entry for 1.1.1.218

• IntEnz: Integrated Enzyme entry for 1.1.1.218

• MetaCyc entry for 1.1.1.218

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0050109: morphine 6-dehydrogenase

• AMIGO entry for GO code 0050109: morphine 6-dehydrogenase