Mevaldate reductase (NADPH)

From Wikipedia, the free encyclopedia

In enzymology, a mevaldate reductase (NADPH) (EC 1.1.1.33) is an enzyme that catalyzes the chemical reaction

(R)-mevalonate + NADP⁺ mevaldate + NADPH + H⁺

Thus, the two substrates of this enzyme are (R)-mevalonate and NADP⁺, whereas its 3 products are mevaldate, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (R)-mevalonate:NADP+ oxidoreductase. Other names in common use include mevaldate (reduced nicotinamide adenine dinucleotide phosphate), reductase, and mevaldate reductase (NADPH).

[edit] References

• IUBMB entry for 1.1.1.33
• BRENDA references for 1.1.1.33 (Recommended.)
• PubMed references for 1.1.1.33
• PubMed Central references for 1.1.1.33
• Google Scholar references for 1.1.1.33
• Wolstenholme, G.E.W. and O'Connor, M. (Eds.), CIBA Symposium on the Biosynthesis of Terpenes and Sterols, CIBA Symposium on the Biosynthesis of Terpenes and Sterols, London, 1959, p. 62-74.
• Jakoby, W.B. (Ed.), Enzymatic Basis of Detoxication, vol. 1, Academic Press, New York, 1980, p. 249-260.

[edit] External links

The CAS registry number for this enzyme class is 9028-34-6.

• IUBMB entry for 1.1.1.33

• KEGG entry for 1.1.1.33

• BRENDA entry for 1.1.1.33

• NiceZyme view of 1.1.1.33

• EC2PDB: PDB structures for 1.1.1.33

• PRIAM entry for 1.1.1.33

• PUMA2 entry for 1.1.1.33

• IntEnz: Integrated Enzyme entry for 1.1.1.33

• MetaCyc entry for 1.1.1.33

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0019726: mevaldate reductase (NADPH)

• AMIGO entry for GO code 0019726: mevaldate reductase (NADPH)