Mevaldate reductase

From Wikipedia, the free encyclopedia

In enzymology, a mevaldate reductase (EC 1.1.1.32) is an enzyme that catalyzes the chemical reaction

(R)-mevalonate + NAD⁺ mevaldate + NADH + H⁺

Thus, the two substrates of this enzyme are (R)-mevalonate and NAD⁺, whereas its 3 products are mevaldate, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (R)-mevalonate:NAD+ oxidoreductase. This enzyme is also called mevalonic dehydrogenase.

[edit] References

• IUBMB entry for 1.1.1.32
• BRENDA references for 1.1.1.32 (Recommended.)
• PubMed references for 1.1.1.32
• PubMed Central references for 1.1.1.32
• Google Scholar references for 1.1.1.32
• Schlesinger MJ and Coon MJ (1961). "Reduction of mevaldic acid to mevalonic acid by a partial purified enzyme from liver". J. Biol. Chem. 236: 2421–2424. 

[edit] External links

The CAS registry number for this enzyme class is 9028-33-5.

• IUBMB entry for 1.1.1.32

• KEGG entry for 1.1.1.32

• BRENDA entry for 1.1.1.32

• NiceZyme view of 1.1.1.32

• EC2PDB: PDB structures for 1.1.1.32

• PRIAM entry for 1.1.1.32

• PUMA2 entry for 1.1.1.32

• IntEnz: Integrated Enzyme entry for 1.1.1.32

• MetaCyc entry for 1.1.1.32

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0019727: mevaldate reductase (NAD+)

• AMIGO entry for GO code 0019727: mevaldate reductase (NAD+)