Talk:Metronidazole

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The edit by Johnathonm is probably a copyright violation. It appears that it was copied from a numer of websites. --Clawed 09:47, 18 Apr 2005 (UTC)

(reverted to pre copyvio version--Duk 16:24, 26 Apr 2005 (UTC))

Contents

[edit] Internal vs External Application

Metronidazole appears to be prescribed for both internal and external conditions. The article should be edited (by someone more knowledgable than I) to indicate which side effects are related to which route of administration, as they sound likely to differ. 66.93.1.225 16:35, 11 December 2005 (UTC)

I agree, and I am not qualified to edit the article. I have Rozex, which is an external application of metronidazole. Do I still need to be wary of the alcohol issues? Anubis1975 05:40, 27 January 2006 (UTC)
Hi Anubis, it doesn't look like you need to be concerned about the alcohol interaction. Here's some info on topical metronidazole [1]. --Uthbrian (talk) 06:03, 27 January 2006 (UTC)

[edit] Treatment for alcoholism?

I had a nasty experience with metronidazole when I foolishly drunk alcohol two days after finishing a course of the drug. The article mentions the nauseating effects of this combination but I've since heard that this effect used to prevent relapse in recovering alcoholics. Can anyone confirm this? --DrFod 18:17, 20 January 2006 (UTC)

Yes, I gather metronidazole's effect with alcholol was used as a basis in the creation of the alcohol avoidence drug antabuse. David Ruben Talk 18:55, 20 January 2006 (UTC)

Hmm, information at MedlinePlus recommends a waiting period of at least 3 days after finishing [2]. Peculiarly, one case report suggests that a woman died from the reaction (PMID 8947362). However, it's interesting to note that the link between metronidazole and disulfiram-like reactions is now being disputed (PMID 12022894, PMID 10676835). --Uthbrian (talk) 04:40, 21 January 2006 (UTC)

I have been prescribed metronidazole for Crohn's disease, taking 400mg daily for nearly a year now. After avoiding alcohol for the first few months, I took my GE's advice and tried a couple of beers one night. There was no adverse effect. As the article states - the adverse interaction with alcohol is not automatic - in fact fairly unlikely. My GE put it at about 5% (chance of adverse interaction with alcohol). Have drunk alcohol as per usual ever since with no adverse effects. ````

[edit] Another Use

This drug is also used to treat Hexamita in fish.

[edit] Used on Dogs ?

I took my dog to the vet, were i was given this drug for him. The vet gave me 10 250mg pill's for my dog, after takeing 3 125mg dose's my dog has bumps over 30% of his body

[edit] Acne and metronidazole

Can metronidazole be used in treating acne?Misterx 14:48, 28 February 2007 (UTC)

I have just been given 10 x 200mg tablets for my dog that has diahorrea, oddly, I see that one of the side effects in humans is diahorrea ?  —Preceding unsigned comment added by Bob300w (talk • contribs) 06:54, 9 February 2008 (UTC)

[edit] Amoebic Dysentery from Giardia lamblia?

The article says "Amoebic dysentery due to Entamoeba histolytica or Giardia lamblia" is an indication for use, but (as I understand it) Giardia lamblia is not related to dysentery. Note that neither article references each other. I am not enough of an expert, however, to edit the article. Mike Connors - 17:12, 12 June 2007

Dysentry is just diarrhoea with blood. Amoebic dysentery is caused by Entamoeba histolytica. Giardia, whilst a protozoa, is not an amoeba. These are separate problems and the word "or" should be "and", i.e. "Amoebic dysentery due to Entamoeba histolytica, and Giardia lamblia" - I'll have a go... David Ruben Talk 19:44, 12 June 2007 (UTC)

Please note that Flagyl (metronidazole) was originally produced and marketed by May & Baker Ltd not Pfizer as suggested in the introduction. I worked in the May & Baker research labs. from 1957 to 1972. During that time it came to our notice that an alcoholic sea captain had continued to drink alcohol whilst taking Flagyl. He suffered such a severe reaction that he (reportedly) never drank again. We considered marketing Flagyl as a cure for alcoholism but decided that if a warning was given the patient would choose not to take the medication but it would be unethical if we did not do so. So we dropped the idea. David Clark 11:34 22nd Oct. 2007. —Preceding unsigned comment added by 212.159.59.131 (talk) 08:36, 22 October 2007 (UTC)

[edit] Extreme Foul Taste

This stuff tastes worse than anything I have ever tasted because the manufacturer is too cheap to coat the pill in sugar or something. Can we get some secondary sources on that? 76.85.197.45 (talk) 17:18, 10 February 2008 (UTC)