Methylglyoxal reductase (NADPH-dependent)

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In enzymology, a methylglyoxal reductase (NADPH-dependent) (EC 1.1.1.283) is an enzyme that catalyzes the chemical reaction

lactaldehyde + NADP⁺ $\rightleftharpoons$ methylglyoxal + NADPH + H⁺

Thus, the two substrates of this enzyme are lactaldehyde and NADP⁺, whereas its 3 products are methylglyoxal, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is lactaldehyde:NADP+ oxidoreductase. Other names in common use include lactaldehyde dehydrogenase (NADP+), and Gre2.

[edit] References

IUBMB entry for 1.1.1.283
BRENDA references for 1.1.1.283 (Recommended.)
PubMed references for 1.1.1.283
PubMed Central references for 1.1.1.283
Google Scholar references for 1.1.1.283
Murata K, Fukuda Y, Simosaka M, Watanabe K, Saikusa T, Kimura A (1985). "Metabolism of 2-oxoaldehyde in yeasts. Purification and characterization of NADPH-dependent methylglyoxal-reducing enzyme from Saccharomyces cerevisiae". Eur. J. Biochem. 151: 631–6. doi:10.1111/j.1432-1033.1985.tb09151.x. PMID 3896793.
Johnston M, Chitnis PR, Kohl DH (2003). "Associating protein activities with their genes: rapid identification of a gene encoding a methylglyoxal reductase in the yeast Saccharomyces cerevisiae". Yeast. 20: 545–54. doi:10.1002/yea.979. PMID 12722185.