Methylglyoxal reductase (NADH-dependent)

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In enzymology, a methylglyoxal reductase (NADH-dependent) (EC 1.1.1.78) is an enzyme that catalyzes the chemical reaction

(R)-lactaldehyde + NAD⁺ methylglyoxal + NADH + H⁺

Thus, the two substrates of this enzyme are (R)-lactaldehyde and NAD⁺, whereas its 3 products are methylglyoxal, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (R)-lactaldehyde:NAD+ oxidoreductase. Other names in common use include methylglyoxal reductase, and D-lactaldehyde dehydrogenase. This enzyme participates in pyruvate metabolism.

[edit] References

• IUBMB entry for 1.1.1.78
• BRENDA references for 1.1.1.78 (Recommended.)
• PubMed references for 1.1.1.78
• PubMed Central references for 1.1.1.78
• Google Scholar references for 1.1.1.78
• TING SM, MILLER ON, SELLINGER OZ (1965). "THE METABOLISM OF LACTALDEHYDE. VII. THE OXIDATION OF D-LACTALDEHYDE IN RAT LIVER". Biochim. Biophys. Acta. 97: 407–15. PMID 14323585. 

[edit] External links

The CAS registry number for this enzyme class is 37250-16-1.

• IUBMB entry for 1.1.1.78

• KEGG entry for 1.1.1.78

• BRENDA entry for 1.1.1.78

• NiceZyme view of 1.1.1.78

• EC2PDB: PDB structures for 1.1.1.78

• PRIAM entry for 1.1.1.78

• PUMA2 entry for 1.1.1.78

• IntEnz: Integrated Enzyme entry for 1.1.1.78

• MetaCyc entry for 1.1.1.78

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0019170: methylglyoxal reductase (NADH-dependent)

• AMIGO entry for GO code 0019170: methylglyoxal reductase (NADH-dependent)