Mercury(II) reductase

From Wikipedia, the free encyclopedia

In enzymology, a mercury(II) reductase (EC 1.16.1.1) is an enzyme that catalyzes the chemical reaction

Hg + NADP⁺ + H⁺ $\rightleftharpoons$ Hg₂+ + NADPH

The 3 substrates of this enzyme are Hg, NADP⁺, and H⁺, whereas its two products are Hg2+ and NADPH.

This enzyme belongs to the family of oxidoreductases, specifically those oxidizing metal ion with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is Hg:NADP+ oxidoreductase. Other names in common use include mercuric reductase, mercurate(II) reductase, mercuric ion reductase, mercury reductase, reduced NADP+:mercuric ion oxidoreductase, and mer A.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1ZK7 and 1ZX9.

[edit] References

IUBMB entry for 1.16.1.1
BRENDA references for 1.16.1.1 (Recommended.)
PubMed references for 1.16.1.1
PubMed Central references for 1.16.1.1
Google Scholar references for 1.16.1.1
Fox B, Walsh CT (1982). "Mercuric reductase. Purification and characterization of a transposon-encoded flavoprotein containing an oxidation-reduction-active disulfide". J. Biol. Chem. 257: 2498–503. PMID 6277900.
Fox, BS and Walsh CT (1983). "Mercuric reductase - homology to glutathione-reductase and lipoamide dehydrogenase - iodoacetamide alkylation and sequence of the active-site peptide". Biochemistry 22: 4082–4088.