Mannose-6-phosphate 6-reductase

From Wikipedia, the free encyclopedia

In enzymology, a mannose-6-phosphate 6-reductase (EC 1.1.1.224) is an enzyme that catalyzes the chemical reaction

D-mannitol 1-phosphate + NADP⁺ D-mannose 6-phosphate + NADPH + H⁺

Thus, the two substrates of this enzyme are D-mannitol 1-phosphate and NADP⁺, whereas its 3 products are D-mannose 6-phosphate, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is D-mannitol-1-phosphate:NADP+ 6-oxidoreductase. Other names in common use include NADPH-dependent mannose 6-phosphate reductase, mannose-6-phosphate reductase, 6-phosphomannose reductase, NADP+-dependent mannose-6-P:mannitol-1-P oxidoreductase, NADPH-dependent M6P reductase, and NADPH-mannose-6-P reductase.

[edit] References

• IUBMB entry for 1.1.1.224
• BRENDA references for 1.1.1.224 (Recommended.)
• PubMed references for 1.1.1.224
• PubMed Central references for 1.1.1.224
• Google Scholar references for 1.1.1.224
• Rumpho ME, Edwards GE and Loescher WH (1983). "A pathway for photosynthetic carbon flow to mannitol in celery leaves Activity and localization of key enzymes". Plant Physiol. 73: 869–873. 

[edit] External links

The CAS registry number for this enzyme class is 88747-79-9.

• IUBMB entry for 1.1.1.224

• KEGG entry for 1.1.1.224

• BRENDA entry for 1.1.1.224

• NiceZyme view of 1.1.1.224

• EC2PDB: PDB structures for 1.1.1.224

• PRIAM entry for 1.1.1.224

• PUMA2 entry for 1.1.1.224

• IntEnz: Integrated Enzyme entry for 1.1.1.224

• MetaCyc entry for 1.1.1.224

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0050088: mannose-6-phosphate 6-reductase

• AMIGO entry for GO code 0050088: mannose-6-phosphate 6-reductase