Mannose-1-phosphate guanylyltransferase (GDP)

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In enzymology, a mannose-1-phosphate guanylyltransferase (GDP) (EC 2.7.7.22) is an enzyme that catalyzes the chemical reaction

GDP + alpha-D-mannose 1-phosphate phosphate + GDP-mannose

Thus, the two substrates of this enzyme are GDP and alpha-D-mannose 1-phosphate, whereas its two products are phosphate and GDP-mannose.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is GDP:alpha-D-mannose-1-phosphate guanylyltransferase. This enzyme participates in fructose and mannose metabolism.

Contents 1 Other common names 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Other common names

• GDP mannose phosphorylase
• Mannose 1-phosphate (guanosine diphosphate) guanylyltransferase
• GDP mannose phosphorylase
• GDP-mannose 1-phosphate guanylyltransferase
• Guanosine diphosphate-mannose 1-phosphate guanylyltransferase
• Guanosine diphosphomannose phosphorylase
• Mannose 1-phosphate guanylyltransferase
• GDP:D-mannose-1-phosphate guanylyltransferase

[edit] References

• IUBMB entry for 2.7.7.22
• BRENDA references for 2.7.7.22 (Recommended.)
• PubMed references for 2.7.7.22
• PubMed Central references for 2.7.7.22
• Google Scholar references for 2.7.7.22
• CARMINATTI H, CABIB E (1961). "Phosphorolysis of the pyrophosphate bond of some nucleotides". Biochim. Biophys. Acta. 53: 417–9. doi:10.1016/0006-3002(61)90458-9. PMID 13876695. 

[edit] External links

The CAS registry number for this enzyme class is 9026-31-7.

• IUBMB entry for 2.7.7.22

• KEGG entry for 2.7.7.22

• BRENDA entry for 2.7.7.22

• NiceZyme view of 2.7.7.22

• EC2PDB: PDB structures for 2.7.7.22

• PRIAM entry for 2.7.7.22

• PUMA2 entry for 2.7.7.22

• IntEnz: Integrated Enzyme entry for 2.7.7.22

• MetaCyc entry for 2.7.7.22

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0008928: mannose-1-phosphate guanylyltransferase (GDP)

• AMIGO entry for GO code 0008928: mannose-1-phosphate guanylyltransferase (GDP)