Mannitol 2-dehydrogenase (NADP+)

From Wikipedia, the free encyclopedia

In enzymology, a mannitol 2-dehydrogenase (NADP+) (EC 1.1.1.138) is an enzyme that catalyzes the chemical reaction

D-mannitol + NADP⁺ D-fructose + NADPH + H⁺

Thus, the two substrates of this enzyme are D-mannitol and NADP⁺, whereas its 3 products are D-fructose, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is D-mannitol:NADP+ 2-oxidoreductase. This enzyme is also called mannitol 2-dehydrogenase (NADP+). This enzyme participates in fructose and mannose metabolism.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1H5Q.

[edit] References

• IUBMB entry for 1.1.1.138
• BRENDA references for 1.1.1.138 (Recommended.)
• PubMed references for 1.1.1.138
• PubMed Central references for 1.1.1.138
• Google Scholar references for 1.1.1.138
• EDMUNDOWICZ JM, WRISTON JC Jr (1963). "MANNITOL DEHYDROGENASE FROM AGARICUS CAMPESTRIS". J. Biol. Chem. 238: 3539–41. PMID 14109183. 
• Strobel GA and Kosuge T (1965). "Polyol metabolism in Diplodia viticola Desm". Arch. Biochem. Biophys. 109: 622–626. doi:10.1016/0003-9861(65)90409-1. 

[edit] External links

The CAS registry number for this enzyme class is 37250-68-3.

• IUBMB entry for 1.1.1.138

• KEGG entry for 1.1.1.138

• BRENDA entry for 1.1.1.138

• NiceZyme view of 1.1.1.138

• EC2PDB: PDB structures for 1.1.1.138

• PRIAM entry for 1.1.1.138

• PUMA2 entry for 1.1.1.138

• IntEnz: Integrated Enzyme entry for 1.1.1.138

• MetaCyc entry for 1.1.1.138

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0050085: mannitol 2-dehydrogenase (NADP+)

• AMIGO entry for GO code 0050085: mannitol 2-dehydrogenase (NADP+)