Mannitol 2-dehydrogenase

From Wikipedia, the free encyclopedia

In enzymology, a mannitol 2-dehydrogenase (EC 1.1.1.67) is an enzyme that catalyzes the chemical reaction

D-mannitol + NAD⁺ D-fructose + NADH + H⁺

Thus, the two substrates of this enzyme are D-mannitol and NAD⁺, whereas its 3 products are D-fructose, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is D-mannitol:NAD+ 2-oxidoreductase. Other names in common use include D-mannitol dehydrogenase, and mannitol dehydrogenase. This enzyme participates in fructose and mannose metabolism.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1LJ8 and 1M2W.

[edit] References

• IUBMB entry for 1.1.1.67
• BRENDA references for 1.1.1.67 (Recommended.)
• PubMed references for 1.1.1.67
• PubMed Central references for 1.1.1.67
• Google Scholar references for 1.1.1.67
• Martinez G, Barker HA and Horecker BL (1963). "A specific mannitol dehydrogenase from Lactobacillus brevis". J. Biol. Chem. 238: 1598–1603. 

[edit] External links

The CAS registry number for this enzyme class is 9001-65-4.

• IUBMB entry for 1.1.1.67

• KEGG entry for 1.1.1.67

• BRENDA entry for 1.1.1.67

• NiceZyme view of 1.1.1.67

• EC2PDB: PDB structures for 1.1.1.67

• PRIAM entry for 1.1.1.67

• PUMA2 entry for 1.1.1.67

• IntEnz: Integrated Enzyme entry for 1.1.1.67

• MetaCyc entry for 1.1.1.67

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0050086: mannitol 2-dehydrogenase

• AMIGO entry for GO code 0050086: mannitol 2-dehydrogenase