Mannitol-1-phosphate 5-dehydrogenase

From Wikipedia, the free encyclopedia

In enzymology, a mannitol-1-phosphate 5-dehydrogenase (EC 1.1.1.17) is an enzyme that catalyzes the chemical reaction

D-mannitol 1-phosphate + NAD⁺ $\rightleftharpoons$ D-fructose 6-phosphate + NADH + H⁺

Thus, the two substrates of this enzyme are D-mannitol 1-phosphate and NAD⁺, whereas its 3 products are D-fructose 6-phosphate, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is D-mannitol-1-phosphate:NAD+ 5-oxidoreductase. Other names in common use include hexose reductase, mannitol 1-phosphate dehydrogenase, D-mannitol-1-phosphate dehydrogenase, and fructose 6-phosphate reductase. This enzyme participates in fructose and mannose metabolism.

[edit] References

IUBMB entry for 1.1.1.17
BRENDA references for 1.1.1.17 (Recommended.)
PubMed references for 1.1.1.17
PubMed Central references for 1.1.1.17
Google Scholar references for 1.1.1.17
MARMUR J, HOTCHKISS RD (1955). "Mannitol metabolism, a transferable property of pneumococcus". J. Biol. Chem. 214: 383–96. PMID 14367396.
Wolfe JB and Kaplan NO (1955). "Hexose phosphate and hexose reductase. A. D-Mannitol-1-phosphate dehydrogenase from E. coli". Methods Enzymol. 1: 346–348. doi:10.1016/0076-6879(55)01050-1.
Wolfe JB and Kaplan NO (1956). "D-Mannitol 1-phosphate dehydrogenase from Escherichia coli". J. Biol. Chem. 218: 849–869.