Malate dehydrogenase (NADP+)

From Wikipedia, the free encyclopedia

In enzymology, a malate dehydrogenase (NADP+) (EC 1.1.1.82) is an enzyme that catalyzes the chemical reaction

(S)-malate + NADP⁺ oxaloacetate + NADPH + H⁺

Thus, the two substrates of this enzyme are (S)-malate and NADP⁺, whereas its 3 products are oxaloacetate, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (S)-malate:NADP+ oxidoreductase. Other names in common use include NADP+-malic enzyme, NADP+-malate dehydrogenase, malic dehydrogenase (nicotinamide adenine dinucleotide phosphate), malate NADP+ dehydrogenase, NADP+ malate dehydrogenase, NADP+-linked malate dehydrogenase, and malate dehydrogenase (NADP+). This enzyme participates in pyruvate metabolism and carbon fixation. This enzyme has at least one effector, hn.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1CIV and 7MDH.

[edit] References

• IUBMB entry for 1.1.1.82
• BRENDA references for 1.1.1.82 (Recommended.)
• PubMed references for 1.1.1.82
• PubMed Central references for 1.1.1.82
• Google Scholar references for 1.1.1.82
• Connelly JL, Danner DJ, Bowden JA (1968). "Branched chain alpha-keto acid metabolism. I. Isolation, purification, and partial characterization of bovine liver alpha-ketoisocaproic:alpha-keto-beta-methylvaleric acid dehydrogenase". J. Biol. Chem. 243: 1198–203. PMID 5689906. 
• Johnson HS (1971). "NADP-malate dehydrogenase: photoactivation in leaves of plants with Calvin cycle photosynthesis". Biochem. Biophys. Res. Commun. 43: 703–9. doi:10.1016/0006-291X(71)90672-3. PMID 4397919. 
• Johnson HS, Hatch MD (1970). "Properties and regulation of leaf nicotinamide-adenine dinucleotide phosphate-malate dehydrogenase and 'malic' enzyme in plants with the C4-dicarboxylic acid pathway of photosynthesis". Biochem. J. 119: 273–80. PMID 4395182. 

[edit] External links

The CAS registry number for this enzyme class is 37250-19-4.

• IUBMB entry for 1.1.1.82

• KEGG entry for 1.1.1.82

• BRENDA entry for 1.1.1.82

• NiceZyme view of 1.1.1.82

• EC2PDB: PDB structures for 1.1.1.82

• PRIAM entry for 1.1.1.82

• PUMA2 entry for 1.1.1.82

• IntEnz: Integrated Enzyme entry for 1.1.1.82

• MetaCyc entry for 1.1.1.82

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0046554: malate dehydrogenase (NADP+)

• AMIGO entry for GO code 0046554: malate dehydrogenase (NADP+)