- Mark Addy (born 1964) (actor)
- John Aislabie, (1670 – 1742), politician
- Alcuin (c. 735–804) (Christian scholar)
- Kate Atkinson (born 1951) (author)
- W. H. Auden (1907–1973) (poet)
- John Ball, Lollard priest, rebel
- Joseph Barnby (1838–1896) composer, conductor
- John Barry (born 1933) (composer)
- David Bradley (born 1942) (actor)
- Michael Burns (actor)
- Vincent Cable (born 1943) (politician)
- Jon Champion (born 1965) (broadcaster)
- Guy Mowbray (broadcaster)
- Martyn Clayton (born 1974) (Writer)
- Margaret Clitherow d.1586 (Catholic saint and martyr)
- Constantine the Great (272-337) (Emperor of Rome)
- Judi Dench (born 1934) (actress)
- Frank Dobson (born 1940) (politician)
- Francis Drake (1696–1771) (historian of York)
- Nathan Drake (1766–1836), essayist, physician
- Keith Drinkel (born 1944) (actor)
- Simon Dyson, golfer
- John Earle (c. 1601 – 1665) (clergyman and author)
- William Etty (1787–1849) (painter)
- Guy Fawkes (1570–1606) (Catholic revolutionary)
- John Flaxman (1755–1826) (sculptor, draughtsman)
- Dustin Gee (1942–1986) (comedian)
- Joseph Hansom, (1803-1882), architect, inventer
- Peter Harrison (1716-1775), architect
- George Hennet (1799–1857) (railway contractor, entrepreneur)
- John Edward Christopher Hill (1912–2003) (Marxist historian)
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- Richard Hotham (1722–1799)), property developer, politician
- Frankie Howerd (1917–1992) (comedy actor)
- George Hudson (1800–1871) (railway pioneer, mayor, politician)
- Ivar the Boneless (794–872) (Viking chieftain)
- Sheelagh Kelly (author)
- Capt. Christopher Levett, explorer of New England, first settler of York (present-day Portland), Maine
- Steve McClaren (born 1961) (football manager)
- Andrew Martin, journalist, novelist
- Francis Mason (1799–1874) (missionary)
- John Middleton (1820-1885), architect
- Albert Joseph Moore, (1841–1893), painter
- Thomas Morton (1564–1659) (clergyman)
- William Parsons, 3rd Earl of Rosse (1800–1867), astronomer
- Matthew Poole (1624-1679), theologian
- King Richard III of England
- Benjamin Seebohm Rowntree (1871–1954) (chocolatier, reformer)
- Joseph Rowntree (1836–1925) (chocolatier, philanthropist)
- Laura Sayers (born 1978) (producer)
- Septimius Severus (Roman Emperor) (193-211)
- Siward, Earl of Northumbria (died 1055) (army commander)
- John Snow (1813–1858) (physician)
- Silvanus P. Thompson (1851–1916) (author and electrical engineer)
- William Hepworth Thompson (1810–1886) (classical scholar)
- Henry Scott Tuke (1858–1929) (painter)
- James Hack Tuke (1819–1896) (social campaigner)
- William Tuke (1732–1822), Henry Tuke (1755–1814), Samuel Tuke (1784–1857) and Daniel Hack Tuke (1827–1895) (social campaigners)
- William of York (1110–1154), archbishop, patron saint of York
- Steve Webster MBE (Ten times sidecar world champion)
- Charles Whiting (born 1926), (author)
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