Talk:Lipodystrophy

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[edit] Hi

Hi, in the "Antiretroviral drugs" section, I would like to remove the statement "(mainly the protease inhibitors)" as this is too generic of a "warning". Recent studies by the AIDS Clinical Trials Group (ACTG: http://www.aactg.org/ -- http://aactg.s-3.com/) [article: http://www.aidsmap.com/en/news/D412C57E-5683-415D-B807-04E69DE1AABF.asp] showed that regimens that contain efavirenz, though simple and generally well tolerated, actually appear to INCREASE risk of lipodystrophy, not decrease. Indeed, in the same study, a boosted protease inhibitor regimen (lopinavir/ritonavir; Kaletra) was shown to cause less lipo when partnered with any nucleoside combination. As a result, I believe the field still contains way too many unknowns to make such a broad statement. If anyone disagrees, or can provide specific citation for this statement then let me know. THANKS! ZacWolf 17:28, 30 May 2007 (UTC)