Leucoanthocyanidin reductase

From Wikipedia, the free encyclopedia

In enzymology, a leucoanthocyanidin reductase (EC 1.17.1.3) is an enzyme that catalyzes the chemical reaction

(2R,3S)-catechin + NADP⁺ + H₂O 2,3-trans-3,4-cis-leucocyanidin + NADPH + H⁺

The 3 substrates of this enzyme are (2R,3S)-catechin, NADP⁺, and H₂O, whereas its 3 products are 2,3-trans-3,4-cis-leucocyanidin, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on CH or CH2 group with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (2R,3S)-catechin:NADP+ 4-oxidoreductase. This enzyme is also called leucocyanidin reductase. This enzyme participates in flavonoid biosynthesis.

[edit] References

• IUBMB entry for 1.17.1.3
• BRENDA references for 1.17.1.3 (Recommended.)
• PubMed references for 1.17.1.3
• PubMed Central references for 1.17.1.3
• Google Scholar references for 1.17.1.3
• Tanner GJ, Kristiansen KN (1993). "Synthesis of 3,4-cis-[3H]leucocyanidin and enzymatic reduction to catechin". Anal. Biochem. 209: 274–7. PMID 8470799. 
• Tanner GJ, Francki KT, Abrahams S, Watson JM, Larkin PJ, Ashton AR (2003). "Proanthocyanidin biosynthesis in plants. Purification of legume leucoanthocyanidin reductase and molecular cloning of its cDNA". J. Biol. Chem. 278: 31647–56. PMID 12788945. 

[edit] External links

• IUBMB entry for 1.17.1.3

• KEGG entry for 1.17.1.3

• BRENDA entry for 1.17.1.3

• NiceZyme view of 1.17.1.3

• EC2PDB: PDB structures for 1.17.1.3

• PRIAM entry for 1.17.1.3

• PUMA2 entry for 1.17.1.3

• IntEnz: Integrated Enzyme entry for 1.17.1.3

• MetaCyc entry for 1.17.1.3

• Atomic-resolution structures of enzymes belonging to this class