Lactaldehyde reductase
From Wikipedia, the free encyclopedia
In enzymology, a lactaldehyde reductase (EC 1.1.1.77) is an enzyme that catalyzes the chemical reaction
- (R)[or (S)]-propane-1,2-diol + NAD+
(R)[or (S)]-lactaldehyde + NADH + H+
The 3 substrates of this enzyme are (R)-propane-1,2-diol, (S)-propane-1,2-diol, and NAD+, whereas its 4 products are (R)-lactaldehyde, (S)-lactaldehyde, NADH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (R)[or (S)]-propane-1,2-diol:NAD+ oxidoreductase. Other names in common use include propanediol:nicotinamide adenine dinucleotide (NAD+) oxidoreductase, and L-lactaldehyde:propanediol oxidoreductase. This enzyme participates in pyruvate metabolism and glyoxylate and dicarboxylate metabolism.
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[edit] Structural studies
As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1RRM, 2BI4, and 2BL4.
[edit] References
- IUBMB entry for 1.1.1.77
- BRENDA references for 1.1.1.77 (Recommended.)
- PubMed references for 1.1.1.77
- PubMed Central references for 1.1.1.77
- Google Scholar references for 1.1.1.77
- Ting S-M, Sellinger OZ and Miller ON (1964). "The metabolism of lactaldehyde. VI. The reduction of D- and L-lactaldehyde in rat liver". Biochim. Biophys. Acta 89: 217–225.
[edit] External links
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- The CAS registry number for this enzyme class is 37250-15-0.
[edit] Gene Ontology (GO) codes
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