Lactaldehyde dehydrogenase

From Wikipedia, the free encyclopedia

In enzymology, a lactaldehyde dehydrogenase (EC 1.2.1.22) is an enzyme that catalyzes the chemical reaction

(S)-lactaldehyde + NAD⁺ + H₂O (S)-lactate + NADH + 2 H⁺

The 3 substrates of this enzyme are (S)-lactaldehyde, NAD⁺, and H₂O, whereas its 3 products are (S)-lactate, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (S)-lactaldehyde:NAD+ oxidoreductase. Other names in common use include L-lactaldehyde:NAD+ oxidoreductase, and nicotinamide adenine dinucleotide (NAD+)-linked dehydrogenase. This enzyme participates in pyruvate metabolism.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes 2HG2, 2ILU, 2IMP, and 2OPX.

[edit] References

• IUBMB entry for 1.2.1.22
• BRENDA references for 1.2.1.22 (Recommended.)
• PubMed references for 1.2.1.22
• PubMed Central references for 1.2.1.22
• Google Scholar references for 1.2.1.22
• Rembold H, Simmersbach F (1969). "Catabolism of pteridine cofactors. II. A specific pterin deaminase in rat liver". Biochim. Biophys. Acta. 184: 589–96. PMID 5821022. 
• Sridhara S, Wu TT (1969). "Purification and properties of lactaldehyde dehydrogenase from Escherichia coli". J. Biol. Chem. 244: 5233–8. PMID 4310089. 

[edit] External links

The CAS registry number for this enzyme class is 37250-90-1.

• IUBMB entry for 1.2.1.22

• KEGG entry for 1.2.1.22

• BRENDA entry for 1.2.1.22

• NiceZyme view of 1.2.1.22

• EC2PDB: PDB structures for 1.2.1.22

• PRIAM entry for 1.2.1.22

• PUMA2 entry for 1.2.1.22

• IntEnz: Integrated Enzyme entry for 1.2.1.22

• MetaCyc entry for 1.2.1.22

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0008911: lactaldehyde dehydrogenase

• AMIGO entry for GO code 0008911: lactaldehyde dehydrogenase