User:JonSDSUGrad/Sandbox/TEST SRC
From Wikipedia, the free encyclopedia
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v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)
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| Identifiers | ||
| Symbol(s) | SRC; ASV; SRC1; c-SRC; p60-Src | |
| External IDs | OMIM: 190090 MGI: 98397 HomoloGene: 21120 | |
| Orthologs | ||
| Human | Mouse | |
| Entrez | 6714 | 20779 |
| Ensembl | ENSG00000197122 | ENSMUSG00000027646 |
| Uniprot | P12931 | P05480 |
| Refseq | NM_005417 (mRNA) NP_005408 (protein) |
NM_001025395 (mRNA) NP_001020566 (protein) |
| Location | Chr 20: 35.41 - 35.47 Mb | Chr 2: 157.12 - 157.16 Mb |
| Pubmed search | [1] | [2] |
This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene.
