User:JonSDSUGrad/Sandbox/TEST NR2E3

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nuclear receptor subfamily 2
Identifiers
Symbol(s)	NR2E3; PNR; ESCS; MGC49976; RNR; rd7
External IDs	OMIM: 604485 MGI: 1346317 HomoloGene: 84397
Gene ontology Molecular Function: • transcription factor activity • steroid hormone receptor activity • steroid binding • nucleus • transcription • regulation of transcription, DNA-dependent • transcription from RNA polymerase II promoter • signal transduction • visual perception • phototransduction • zinc ion binding • tRNA-pseudouridine synthase activity • sequence-specific DNA binding • metal ion binding • response to stimulus
Orthologs
	Human	Mouse
Entrez	10002	23958
Ensembl	ENSG00000031544	ENSMUSG00000032292
Uniprot	Q9Y5X4	Q9QXZ7
Refseq	NM_014249 (mRNA) NP_055064 (protein)	NM_013708 (mRNA) NP_038736 (protein)
Location	Chr 15: 69.89 - 69.9 Mb	Chr 9: 59.74 - 59.75 Mb
Pubmed search	[1]	[2]

This protein is part of a large family of nuclear receptor transcription factors involved in signaling pathways. Nuclear receptors have been shown to regulate pathways involved in embryonic development, as well as in maintenance of proper cell function in adults. Members of this family are characterized by discrete domains that function in DNA and ligand binding. This gene encodes a retinal nuclear receptor that is a ligand-dependent transcription factor. Defects in this gene are a cause of enhanced S cone syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified.

Automatic update 1