User:JonSDSUGrad/Sandbox/TEST ITK

From Wikipedia, the free encyclopedia

IL2-inducible T-cell kinase
Identifiers
Symbol(s)	ITK; PSCTK2; EMT; LYK; MGC126257; MGC126258
External IDs	OMIM: 186973 MGI: 96621 HomoloGene: 4051
Gene ontology Molecular Function: • nucleotide binding • non-membrane spanning protein tyrosine kinase activity • ATP binding • protein amino acid phosphorylation • cellular defense response • intracellular signaling cascade • zinc ion binding • kinase activity • transferase activity • metal ion binding
Orthologs
	Human	Mouse
Entrez	3702	16428
Ensembl	ENSG00000113263	ENSMUSG00000020395
Uniprot	Q08881	Q03526
Refseq	NM_005546 (mRNA) NP_005537 (protein)	NM_010583 (mRNA) NP_034713 (protein)
Location	Chr 5: 156.54 - 156.61 Mb	Chr 11: 46.17 - 46.23 Mb
Pubmed search	[1]	[2]

This gene encodes an intracellular tyrosine kinase expressed in T-cells. The protein contains both SH2 and SH3 domains which are often found in intracellular kinases. It is thought to play a role in T-cell proliferation and differentiation.

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