User:JonSDSUGrad/Sandbox/TEST ICMT

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isoprenylcysteine carboxyl methyltransferase
Identifiers
Symbol(s)	ICMT; HSTE14; MGC39955; MST098; MSTP098; PCCMT; PCMT; PPMT
External IDs	OMIM: 605851 MGI: 1888594 HomoloGene: 5735
Gene ontology Molecular Function: • protein-S-isoprenylcysteine O-methyltransferase activity • membrane fraction • endoplasmic reticulum • protein modification process • C-terminal protein amino acid methylation • protein targeting to membrane • protein localization • methyltransferase activity • membrane • integral to membrane • transferase activity
Orthologs
	Human	Mouse
Entrez	23463	57295
Ensembl	ENSG00000116237	ENSMUSG00000039662
Uniprot	O60725	Q9EQK7
Refseq	NM_012405 (mRNA) NP_036537 (protein)	NM_133788 (mRNA) NP_598549 (protein)
Location	Chr 1: 6.2 - 6.22 Mb	Chr 4: 151.14 - 151.15 Mb
Pubmed search	[1]	[2]

This gene encodes the third of three enzymes that posttranslationally modify isoprenylated C-terminal cysteine residues in certain proteins and target those proteins to the cell membrane. This enzyme localizes to the endoplasmic reticulum. Alternative splicing may result in other transcript variants, but the biological validity of those transcripts has not been determined.

Automatic update 1