User:JonSDSUGrad/Sandbox/TEST ESR1

From Wikipedia, the free encyclopedia

estrogen receptor 1
Identifiers
Symbol(s)	ESR1; ER; DKFZp686N23123; ESR; ESRA; Era; NR3A1
External IDs	OMIM: 133430 MGI: 1352467 HomoloGene: 47906
Gene ontology Molecular Function: • DNA binding • transcription factor activity • steroid hormone receptor activity • receptor activity • steroid binding • protein binding • nucleus • cytoplasm • regulation of transcription, DNA-dependent • signal transduction • zinc ion binding • lipid binding • membrane • cell growth • chromatin remodeling complex • nitric-oxide synthase regulator activity • estrogen receptor activity • estrogen receptor signaling pathway • sequence-specific DNA binding • negative regulation of mitosis • metal ion binding
Orthologs
	Human	Mouse
Entrez	2099	13982
Ensembl	ENSG00000091831	ENSMUSG00000019768
Uniprot	P03372	P19785
Refseq	NM_000125 (mRNA) NP_000116 (protein)	XM_985634 (mRNA) XP_990728 (protein)
Location	Chr 6: 152.17 - 152.47 Mb	Chr 10: 5.34 - 5.73 Mb
Pubmed search	[1]	[2]

The estrogen receptor (ESR) is a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. Alternative splicing results in several ESR1 mRNA transcripts, which differ primarily in their 5-prime untranslated regions. The translated receptors show less variability.[supplied by OMIM]