User:JonSDSUGrad/Sandbox/TEST7 Src (gene)

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v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)
PDB rendering based on 1a07.
Available structures: 1a07, 1a08, 1a09, 1a1a, 1a1b, 1a1c, 1a1e, 1bkl, 1bkm, 1f1w, 1f2f, 1fmk, 1hcs, 1hct, 1is0, 1kc2, 1ksw, 1nlo, 1nlp, 1nzl, 1nzv, 1o41, 1o42, 1o43, 1o44, 1o45, 1o46, 1o47, 1o48, 1o49, 1o4a, 1o4b, 1o4c, 1o4d, 1o4e, 1o4f, 1o4g, 1o4h, 1o4i, 1o4j, 1o4k, 1o4l, 1o4m, 1o4n, 1o4o, 1o4p, 1o4q, 1o4r, 1p13, 1prl, 1prm, 1qwe, 1qwf, 1rlp, 1rlq, 1sha, 1shb, 1shd, 1skj, 1spr, 1sps, 1srl, 1srm, 1y57, 1yi6, 1yoj, 1yol, 1yom, 2bdf, 2bdj, 2h8h, 2hwo, 2hwp, 2oiq, 2ptk, 2src
Identifiers
Symbol(s) SRC; ASV; SRC1; c-SRC; p60-Src
External IDs OMIM: 190090 MGI: 98397 HomoloGene: 21120
Orthologs
Human Mouse
Entrez 6714 20779
Ensembl ENSG00000197122 ENSMUSG00000027646
Uniprot P12931 n/a
Refseq NM_005417 (mRNA)
NP_005408 (protein)		 NM_001025395 (mRNA)
NP_001020566 (protein)
Location Chr 20: 35.41 - 35.47 Mb Chr 2: 157.12 - 157.16 Mb
Pubmed search [1] [2]

[edit] Summary

This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene.[1]

[edit] References

  1. ^ Entrez Gene: SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian). Retrieved on 2007-08-07.

[edit] Further reading

  • Frame MC, Fincham VJ, Carragher NO, Wyke JA (2002). "v-Src's hold over actin and cell adhesions.". Nature reviews. Molecular cell biology 3 (4): 233-45. doi:10.1038/nrm779. PMID 11994743. 
  • Benaim G, Villalobo A (2002). "Phosphorylation of calmodulin. Functional implications.". European journal of biochemistry / FEBS 269 (15): 3619-31. PMID 12153558. 
  • Simeonova PP, Luster MI (2003). "Arsenic carcinogenicity: relevance of c-Src activation.". Molecular and cellular biochemistry 234-235 (1-2): 277-82. PMID 12162444. 
  • Leu TH, Maa MC (2004). "Functional implication of the interaction between EGF receptor and c-Src.". Frontiers in bioscience : a journal and virtual library 8: s28-38. PMID 12456372. 
  • Greenway AL, Holloway G, McPhee DA, Ellis P, Cornall A, Lidman M (2004). "HIV-1 Nef control of cell signalling molecules: multiple strategies to promote virus replication.". Journal of biosciences 28 (3): 323-35. PMID 12734410. 
  • Dehm SM, Bonham K (2004). "SRC gene expression in human cancer: the role of transcriptional activation.". Biochemistry and cell biology = Biochimie et biologie cellulaire 82 (2): 263-74. doi:10.1139/o03-077. PMID 15060621. 
  • Tolstrup M, Ostergaard L, Laursen AL, Pedersen SF, Duch M (2004). "HIV/SIV escape from immune surveillance: focus on Nef.". Current HIV research 2 (2): 141-51. PMID 15078178. 
  • Joseph AM, Kumar M, Mitra D (2005). "Nef: "necessary and enforcing factor" in HIV infection.". Current HIV research 3 (1): 87-94. PMID 15638726. 
  • Roskoski R (2005). "Src kinase regulation by phosphorylation and dephosphorylation.". Biochemical and biophysical research communications 331 (1): 1-14. doi:10.1016/j.bbrc.2005.03.012. PMID 15845350. 
  • Alper O, Bowden ET (2005). "Novel insights into c-Src.". Current pharmaceutical design 11 (9): 1119-30. PMID 15853660.