User:JonSDSUGrad/Sandbox/TEST7 MMP9

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matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
PDB rendering based on 1itv.
Available structures: 1itv, 1l6j
Identifiers
Symbol(s) MMP9; CLG4B; GELB; MMP-9
External IDs OMIM: 120361 MGI: 97011 HomoloGene: 3659
Orthologs
Human Mouse
Entrez 4318 17395
Ensembl ENSG00000100985 ENSMUSG00000017737
Uniprot P14780 n/a
Refseq NM_004994 (mRNA)
NP_004985 (protein)		 NM_013599 (mRNA)
NP_038627 (protein)
Location Chr 20: 44.07 - 44.08 Mb Chr 2: 164.64 - 164.65 Mb
Pubmed search [1] [2]

[edit] Summary

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling.[1]

[edit] References

  1. ^ Entrez Gene: MMP9 matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase). Retrieved on 2007-08-07.

[edit] Further reading

  • Nagase H, Woessner JF (1999). "Matrix metalloproteinases.". The Journal of biological chemistry 274 (31): 21491-4. PMID 10419448. 
  • Starckx S, Van den Steen PE, Wuyts A, Van Damme J, Opdenakker G (2003). "Neutrophil gelatinase B and chemokines in leukocytosis and stem cell mobilization.". Leukemia & lymphoma 43 (2): 233-41. PMID 11999552. 
  • Bischof P, Meisser A, Campana A (2002). "Control of MMP-9 expression at the maternal-fetal interface.". Journal of reproductive immunology 55 (1-2): 3-10. PMID 12062817. 
  • St-Pierre Y, Van Themsche C, Estève PO (2003). "Emerging features in the regulation of MMP-9 gene expression for the development of novel molecular targets and therapeutic strategies.". Current drug targets. Inflammation and allergy 2 (3): 206-15. PMID 14561155. 
  • Lee JM, Yin K, Hsin I, Chen S, Fryer JD, Holtzman DM, Hsu CY, Xu J (2005). "Matrix metalloproteinase-9 in cerebral-amyloid-angiopathy-related hemorrhage.". Journal of the neurological sciences 229-230: 249-54. doi:10.1016/j.jns.2004.11.041. PMID 15760647. 
  • Nair RR, Boyd DD (2006). "Expression cloning of novel regulators of 92 kDa type IV collagenase expression.". Biochemical Society transactions 33 (Pt 5): 1135-6. doi:10.1042/BST20051135. PMID 16246065. 
  • Ram M, Sherer Y, Shoenfeld Y (2006). "Matrix metalloproteinase-9 and autoimmune diseases.". Journal of clinical immunology 26 (4): 299-307. doi:10.1007/s10875-006-9022-6. PMID 16652230.