User:JonSDSUGrad/Sandbox/TEST7 Insulin-like growth factor 1

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insulin-like growth factor 1 (somatomedin C)
PDB rendering based on 1bqt.
Available structures: 1bqt, 1gzr, 1gzy, 1gzz, 1h02, 1h59, 1imx, 1pmx, 1wqj, 2dsp, 2dsq, 2dsr, 2gf1, 3gf1, 3lri
Identifiers
Symbol(s) IGF1; IGFI
External IDs OMIM: 147440 MGI: 96432 HomoloGene: 515
Orthologs
Human Mouse
Entrez 3479 16000
Ensembl ENSG00000017427 ENSMUSG00000020053
Uniprot P01343 n/a
Refseq NM_000618 (mRNA)
NP_000609 (protein)		 NM_010512 (mRNA)
NP_034642 (protein)
Location Chr 12: 101.31 - 101.4 Mb Chr 10: 87.29 - 87.36 Mb
Pubmed search [1] [2]

[edit] Summary

The somatomedins, or insulin-like growth factors (IGFs), comprise a family of peptides that play important roles in mammalian growth and development. IGF1 mediates many of the growth-promoting effects of growth hormone (GH; MIM 139250). Early studies showed that growth hormone did not directly stimulate the incorporation of sulfate into cartilage, but rather acted through a serum factor, termed 'sulfation factor,' which later became known as 'somatomedin' (Daughaday et al., 1972). Three main somatomedins have been characterized: somatomedin C (IGF1), somatomedin A (IGF2; MIM 147470), and somatomedin B (MIM 193190) (Rotwein, 1986; Rosenfeld, 2003).[supplied by OMIM][1]

[edit] References

  1. ^ Entrez Gene: IGF1 insulin-like growth factor 1 (somatomedin C). Retrieved on 2007-08-07.

[edit] Further reading

  • Butler AA, Yakar S, LeRoith D (2002). "Insulin-like growth factor-I: compartmentalization within the somatotropic axis?". News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society 17: 82-5. PMID 11909998. 
  • Maccario M, Tassone F, Grottoli S, Rossetto R, Gauna C, Ghigo E (2002). "Neuroendocrine and metabolic determinants of the adaptation of GH/IGF-I axis to obesity.". Annales d'endocrinologie 63 (2 Pt 1): 140-4. PMID 11994678. 
  • Camacho-Hübner C, Woods KA, Clark AJ, Savage MO (2003). "Insulin-like growth factor (IGF)-I gene deletion.". Reviews in endocrine & metabolic disorders 3 (4): 357-61. PMID 12424437. 
  • Trojan LA, Kopinski P, Wei MX, Ly A, Glogowska A, Czarny J, Shevelev A, Przewlocki R, Henin D, Trojan J (2004). "IGF-I: from diagnostic to triple-helix gene therapy of solid tumors.". Acta biochimica Polonica 49 (4): 979-90. doi:024904979. PMID 12545204. 
  • Winn N, Paul A, Musaró A, Rosenthal N (2003). "Insulin-like growth factor isoforms in skeletal muscle aging, regeneration, and disease.". Cold Spring Harbor symposia on quantitative biology 67: 507-18. PMID 12858577. 
  • Delafontaine P, Song YH, Li Y (2005). "Expression, regulation, and function of IGF-1, IGF-1R, and IGF-1 binding proteins in blood vessels.". Arteriosclerosis, thrombosis, and vascular biology 24 (3): 435-44. doi:10.1161/01.ATV.0000105902.89459.09. PMID 14604834. 
  • Trejo JL, Carro E, Garcia-Galloway E, Torres-Aleman I (2004). "Role of insulin-like growth factor I signaling in neurodegenerative diseases.". Journal of molecular medicine (Berlin, Germany) 82 (3): 156-62. doi:10.1007/s00109-003-0499-7. PMID 14647921. 
  • Rabinovsky ED (2004). "The multifunctional role of IGF-1 in peripheral nerve regeneration.". Neurological research 26 (2): 204-10. doi:10.1179/016164104225013851. PMID 15072640. 
  • Rincon M, Muzumdar R, Atzmon G, Barzilai N (2005). "The paradox of the insulin/IGF-1 signaling pathway in longevity.". Mechanisms of ageing and development 125 (6): 397-403. PMID 15272501. 
  • Conti E, Carrozza C, Capoluongo E, Volpe M, Crea F, Zuppi C, Andreotti F (2005). "Insulin-like growth factor-1 as a vascular protective factor.". Circulation 110 (15): 2260-5. doi:10.1161/01.CIR.0000144309.87183.FB. PMID 15477425. 
  • Wood AW, Duan C, Bern HA (2005). "Insulin-like growth factor signaling in fish.". International review of cytology 243: 215-85. doi:10.1016/S0074-7696(05)43004-1. PMID 15797461. 
  • Sandhu MS (2005). "Insulin-like growth factor-I and risk of type 2 diabetes and coronary heart disease: molecular epidemiology.". Endocrine development 9: 44-54. doi:10.1159/000085755. PMID 15879687. 
  • Ye P, D'Ercole AJ (2006). "Insulin-like growth factor actions during development of neural stem cells and progenitors in the central nervous system.". Journal of neuroscience research 83 (1): 1-6. doi:10.1002/jnr.20688. PMID 16294334. 
  • Gómez JM (2006). "The role of insulin-like growth factor I components in the regulation of vitamin D.". Current pharmaceutical biotechnology 7 (2): 125-32. PMID 16724947. 
  • Federico G, Street ME, Maghnie M, Caruso-Nicoletti M, Loche S, Bertelloni S, Cianfarani S, , (2006). "Assessment of serum IGF-I concentrations in the diagnosis of isolated childhood-onset GH deficiency: a proposal of the Italian Society for Pediatric Endocrinology and Diabetes (SIEDP/ISPED).". Journal of endocrinological investigation 29 (8): 732-7. PMID 17033263. 
  • Zakula Z, Koricanac G, Putnikovic B, Markovic L, Isenovic ER (2007). "Regulation of the inducible nitric oxide synthase and sodium pump in type 1 diabetes.". Medical hypotheses 69 (2): 302-6. doi:10.1016/j.mehy.2006.11.045. PMID 17289286. 
  • Trojan J, Cloix JF, Ardourel MY, Chatel M, Anthony DD (2007). "Insulin-like growth factor type I biology and targeting in malignant gliomas.". Neuroscience 145 (3): 795-811. doi:10.1016/j.neuroscience.2007.01.021. PMID 17320297.