User:JonSDSUGrad/Sandbox/TEST7 Beta-catenin

From Wikipedia, the free encyclopedia

catenin (cadherin-associated protein), beta 1, 88kDa
PDB rendering based on 1dow.
Available structures: 1dow, 1g3j, 1i7w, 1i7x, 1jdh, 1jpp, 1jpw, 1luj, 1m1e, 1qz7, 1t08, 1th1, 1v18, 2bct, 2gl7, 3bct
Identifiers
Symbol(s)	CTNNB1; CTNNB; FLJ25606
External IDs	OMIM: 116806 MGI: 88276 HomoloGene: 1434
Gene ontology Molecular Function: • negative regulation of transcription from RNA polymerase II promoter • cellular morphogenesis during differentiation • skeletal development • patterning of blood vessels • endoderm formation • cell fate specification • cell fate determination • endodermal cell fate commitment • chromatin binding • transcription factor activity • transcription coactivator activity • signal transducer activity • structural molecule activity • binding • membrane fraction • nucleus • transcription factor complex • cytoplasm • cytoskeleton • plasma membrane • cell-cell adherens junction • synaptic transmission • ectoderm development • heart development • dorsal/ventral axis specification • proximal/distal pattern formation • gastrulation (sensu Mammalia) • Wnt receptor signaling pathway • basolateral plasma membrane • lateral plasma membrane • morphogenesis of embryonic epithelium • cell-cell adhesion • lamellipodium • hemopoiesis • osteoclast differentiation • lung development • androgen receptor signaling pathway • positive regulation of epithelial cell differentiation • forebrain development • pancreas development • microvillus membrane • embryonic hindlimb morphogenesis • embryonic arm morphogenesis • regulation of cell proliferation • odontogenesis (sensu Vertebrata) • embryonic digit morphogenesis • apical part of cell • alpha-catenin binding • cadherin binding • bone resorption • negative regulation of cell differentiation • positive regulation of osteoblast differentiation • negative regulation of osteoclast differentiation • positive regulation of transcription from RNA polymerase II promoter • cell maturation • synaptic vesicle transport • androgen receptor binding • synapse organization and biogenesis
Orthologs
	Human	Mouse
Entrez	1499	12387
Ensembl	ENSG00000168036	ENSMUSG00000006932
Uniprot	P35222	n/a
Refseq	XM_001133660 (mRNA) XP_001133660 (protein)	NM_007614 (mRNA) NP_031640 (protein)
Location	Chr 3: 41.22 - 41.26 Mb	Chr 9: 120.78 - 120.81 Mb
Pubmed search	[1]	[2]

[edit] Summary

Beta-catenin is an adherens junction protein. Adherens junctions (AJs; also called the zonula adherens) are critical for the establishment and maintenance of epithelial layers, such as those lining organ surfaces. AJs mediate adhesion between cells, communicate a signal that neighboring cells are present, and anchor the actin cytoskeleton. In serving these roles, AJs regulate normal cell growth and behavior. At several stages of embryogenesis, wound healing, and tumor cell metastasis, cells form and leave epithelia. This process, which involves the disruption and reestablishment of epithelial cell-cell contacts, may be regulated by the disassembly and assembly of AJs. AJs may also function in the transmission of the 'contact inhibition' signal, which instructs cells to stop dividing once an epithelial sheet is complete.[supplied by OMIM]^[1]

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[edit] Further reading