User:JonSDSUGrad/Sandbox/TEST6 Retinoblastoma protein

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retinoblastoma 1 (including osteosarcoma)

PDB rendering based on 1ad6.

Available structures: 1ad6, 1gh6, 1gux, 1o9k, 2aze

Identifiers

Symbol(s)

RB1; OSRC; RB

External IDs

OMIM: 180200 MGI: 97874 HomoloGene: 272

Gene ontology
Molecular Function:	• cell cycle checkpoint • G1/S transition of mitotic cell cycle • negative regulation of transcription from RNA polymerase II promoter • M phase • chromatin • molecular_function • transcription factor activity • transcription coactivator activity • nucleus • transcription factor complex • spindle • transcription • regulation of transcription, DNA-dependent • negative regulation of protein kinase activity • cell cycle • cell cycle arrest • transcription factor binding • negative regulation of cell proliferation • transcription repressor activity • kinase binding • negative regulation of cell growth • androgen receptor signaling pathway • regulation of lipid kinase activity • positive regulation of transcription from RNA polymerase II promoter • androgen receptor binding • striated muscle cell differentiation • cell division • G1 phase

Orthologs

Human

Mouse

n/a

Refseq

NM_000321 (mRNA)
NP_000312 (protein)

NM_009029 (mRNA)
NP_033055 (protein)

Location

Chr 13: 47.78 - 47.95 Mb

Chr 14: 71.93 - 72.06 Mb

Pubmed search

[1]

[2]

[edit] Summary

Retinoblastoma (RB) is an embryonic malignant neoplasm of retinal origin. It almost always presents in early childhood and is often bilateral. Spontaneous regression ('cure') occurs in some cases.[supplied by OMIM]^[1]