User:JonSDSUGrad/Sandbox/TEST6 HIF1A

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< User:JonSDSUGrad | Sandbox

hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)

PDB rendering based on 1h2k.

Available structures: 1h2k, 1h2l, 1h2m, 1l3e, 1l8c, 1lqb

Identifiers

Symbol(s)

HIF1A; HIF-1alpha; HIF1-ALPHA; MOP1; PASD8

External IDs

OMIM: 603348 MGI: 106918 HomoloGene: 1171

Gene ontology
Molecular Function:	• angiogenesis • response to hypoxia • neural crest cell migration • heart looping • RNA polymerase II transcription factor activity, enhancer binding • signal transducer activity • protein binding • nucleus • regulation of transcription, DNA-dependent • signal transduction • microtubule-based flagellum • cell differentiation • histone acetyltransferase binding • homeostatic process • regulation of apoptosis • positive regulation of transcription • positive regulation of transcription from RNA polymerase II promoter • protein heterodimerization activity

Orthologs

Human

Mouse

n/a

Refseq

NM_001530 (mRNA)
NP_001521 (protein)

NM_010431 (mRNA)
NP_034561 (protein)

Location

Chr 14: 61.23 - 61.28 Mb

Chr 12: 74.83 - 74.87 Mb

Pubmed search

[1]

[2]

[edit] Summary

Hypoxia-inducible factor-1 (HIF1) is a transcription factor found in mammalian cells cultured under reduced oxygen tension that plays an essential role in cellular and systemic homeostatic responses to hypoxia. HIF1 is a heterodimer composed of an alpha subunit and a beta subunit. The beta subunit has been identified as the aryl hydrocarbon receptor nuclear translocator (ARNT). This gene encodes the alpha subunit of HIF-1. Overexpression of a natural antisense transcript (aHIF) of this gene has been shown to be associated with nonpapillary renal carcinomas. Two alternative transcripts encoding different isoforms have been identified.^[1]