User:JonSDSUGrad/Sandbox/TEST4 CASP3

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caspase 3
[http:\www.pdb.org PDB] rendering based on 1cp3.
Available structures: 1cp3, 1gfw, 1i3o, 1nme, 1nmq, 1nms, 1pau, 1qx3, 1re1, 1rhj, 1rhk, 1rhm, 1rhq, 1rhr, 1rhu, 2c1e, 2c2k, 2c2m, 2c2o, 2cdr, 2cjx, 2cjy, 2cnk, 2cnl, 2cnn, 2cno, 2dko, 2h5i, 2h5j, 2h65, 2j30, 2j31, 2j32, 2j33
Identifiers
Symbol(s)	CASP3; CPP32; CPP32B; SCA-1
External IDs	OMIM: 600636 MGI: 107739 HomoloGene: 37912
Gene ontology Molecular Function: • B cell homeostasis • release of cytochrome c from mitochondria • cyclin-dependent protein kinase inhibitor activity • protein binding • cytoplasm • DNA fragmentation during apoptosis • proteolysis • apoptosis • induction of apoptosis • heart development • sensory perception of sound • cysteine-type peptidase activity • induction of apoptosis via death domain receptors • induction of apoptosis by oxidative stress • response to UV • response to wounding • keratinocyte differentiation • caspase activity • negative regulation of B cell proliferation • T cell homeostasis • cell fate commitment • negative regulation of cyclin-dependent protein kinase activity • negative regulation of activated T cell proliferation
Orthologs
	Human	Mouse
Entrez	836	12367
Ensembl	ENSG00000164305	ENSMUSG00000031628
Uniprot	P42574	n/a
Refseq	NM_004346 (mRNA) NP_004337 (protein)	XM_991820 (mRNA) XP_996914 (protein)
Location	Chr 4: 185.79 - 185.81 Mb	Chr 8: 48.12 - 48.14 Mb
Pubmed search	[1]	[2]