User:JonSDSUGrad/Sandbox/TEST4 APP

From Wikipedia, the free encyclopedia

amyloid beta (A4) precursor protein (peptidase nexin-II
[http:\www.pdb.org PDB] rendering based on 1aap.
Available structures: 1aap, 1amb, 1amc, 1aml, 1ba4, 1ba6, 1brc, 1ca0, 1iyt, 1mwp, 1owt, 1rw6, 1taw, 1tkn, 1z0q, 1zjd, 2beg, 2fjz, 2fk1, 2fk2, 2fk3, 2fkl, 2fma, 2g47
Identifiers
Symbol(s)	APP; AAA; ABETA; ABPP; AD1; APPI; CTFgamma; CVAP; PN2
External IDs	OMIM: 104760 MGI: 88059 HomoloGene: 56379
Gene ontology Molecular Function: • G2 phase of mitotic cell cycle • suckling behavior • DNA binding • serine-type endopeptidase inhibitor activity • binding • iron ion binding • copper ion binding • extracellular region • membrane fraction • cytoplasm • Golgi apparatus • integral to plasma membrane • coated pit • mRNA polyadenylation • cellular copper ion homeostasis • endocytosis • apoptosis • cell adhesion • Notch signaling pathway • axonogenesis • mating behavior • axon cargo transport • heparin binding • zinc ion binding • adult locomotory behavior • visual learning • cell surface • membrane • integral to membrane • axon midline choice point recognition • neuron remodeling • dendrite development • extracellular matrix organization and biogenesis • axon • forebrain development • cytoplasmic vesicle • neuromuscular junction • ciliary rootlet • regulation of body size • identical protein binding • apical part of cell • positive regulation of progression through mitotic cell cycle • positive regulation of transcription from RNA polymerase II promoter • metal ion binding • perinuclear region of cytoplasm • collateral sprouting in the absence of injury • regulation of synapse structure and activity • regulation of balance • neuromuscular process • synaptic growth at neuromuscular junction • spindle midzone • smooth endoplasmic reticulum calcium ion homeostasis
Orthologs
	Human	Mouse
Entrez	351	11820
Ensembl	ENSG00000142192	ENSMUSG00000022892
Uniprot	P05067	n/a
Refseq	NM_000484 (mRNA) NP_000475 (protein)	NM_007471 (mRNA) NP_031497 (protein)
Location	Chr 21: 26.17 - 26.47 Mb	Chr 16: 84.84 - 85.06 Mb
Pubmed search	[1]	[2]