User:JonSDSUGrad/Sandbox/TEST1 EGR1

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Early growth response 1

PDB rendering based on 1a1f.

Available structures: 1a1f, 1a1g, 1a1h, 1a1i, 1a1j, 1a1k, 1a1l, 1aay, 1f2i, 1jk1, 1jk2, 1p47, 1zaa

Identifiers

Symbol(s)

EGR1; AT225; G0S30; KROX-24; NGFI-A; TIS8; ZIF-268; ZNF225

External IDs

OMIM: 128990 MGI: 95295 HomoloGene: 56394

Gene ontology
Molecular Function:	• transcription factor activity • zinc ion binding • metal ion binding
Cellular Component:	• intracellular • nucleus
Biological Process:	• transcription • regulation of transcription, DNA-dependent • T cell differentiation • positive regulation of transcription

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001964 (mRNA)
NP_001955 (protein)

NM_007913 (mRNA)
NP_031939 (protein)

Location

Chr 5: 137.83 - 137.83 Mb

Chr 18: 34.99 - 34.99 Mb

Pubmed search

[1]

[2]

Early growth response 1, also known as EGR1, is a human gene.

The protein encoded by this gene belongs to the EGR family of C2H2-type zinc-finger proteins. It is a nuclear protein and functions as a transcriptional regulator. The products of target genes it activates are required for differentitation and mitogenesis. Studies suggest this is a cancer suppresor gene.^[1]

[edit] References

^ Entrez Gene: EGR1 early growth response 1.

[edit] Further reading

Heath RG (1975). "Brain function and behavior. I. Emotion and sensory phenomena in psychotic patients and in experimental animals.". J. Nerv. Ment. Dis. 160 (3): 159-75. PMID 1090709.
Silverman ES, Collins T (1999). "Pathways of Egr-1-mediated gene transcription in vascular biology.". Am. J. Pathol. 154 (3): 665-70. PMID 10079243.
Adamson ED, Mercola D (2002). "Egr1 transcription factor: multiple roles in prostate tumor cell growth and survival.". Tumour Biol. 23 (2): 93-102. PMID 12065847.
Blaschke F, Bruemmer D, Law RE (2004). "Egr-1 is a major vascular pathogenic transcription factor in atherosclerosis and restenosis.". Reviews in endocrine & metabolic disorders 5 (3): 249-54. doi:10.1023/B:REMD.0000032413.88756.ee. PMID 15211096.
Abdulkadir SA (2006). "Mechanisms of prostate tumorigenesis: roles for transcription factors Nkx3.1 and Egr1.". Ann. N. Y. Acad. Sci. 1059: 33-40. doi:10.1196/annals.1339.018. PMID 16382041.