Inositol 2-dehydrogenase

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In enzymology, an inositol 2-dehydrogenase (EC 1.1.1.18) is an enzyme that catalyzes the chemical reaction

myo-inositol + NAD⁺ $\rightleftharpoons$ 2,4,6/3,5-pentahydroxycyclohexanone + NADH + H⁺

Thus, the two substrates of this enzyme are myo-inositol and NAD⁺, whereas its 3 products are 2,4,6/3,5-pentahydroxycyclohexanone, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is myo-inositol:NAD+ 2-oxidoreductase. Other names in common use include myo-inositol 2-dehydrogenase, myo-inositol:NAD+ oxidoreductase, inositol dehydrogenase, and myo-inositol dehydrogenase. This enzyme participates in inositol metabolism and inositol phosphate metabolism.

[edit] References

IUBMB entry for 1.1.1.18
BRENDA references for 1.1.1.18 (Recommended.)
PubMed references for 1.1.1.18
PubMed Central references for 1.1.1.18
Google Scholar references for 1.1.1.18
Berman T, Magasanik B (1966). "The pathway of myo-inositol degradation in Aerobacter aerogenes Dehydrogenation and dehydration". J. Biol. Chem. 241: 800–6. PMID 5905122.
LARNER J, JACKSON WT, GRAVES DJ, STAMER JR (1956). "Inositol dehydrogenase from Aerobacter aerogenes". Arch. Biochem. Biophys. 60: 352–63. PMID 13292912.
Vidal-Leiria M, van Uden N (1973). "Inositol dehydrogenase from the yeast Cryptococcus melibiosum". Biochim. Biophys. Acta. 293: 295–303. PMID 4351258.