Talk:Hypersensitivity
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Type 1 - immediate (or atopic, or anaphylactic)
Main article: Allergy
Type 1 hypersensitivity is an allergic reaction provoked by reexposure to a specific type of antigen referred to as an allergen.[3] Exposure may be by ingestion, inhalation, injection, or direct contact. The difference between a normal immune response and a type I hypersensitive response is that plasma cells secrete IgE. THIS SENTANCE DOES NOTHING TO CLARIFY THE DIFFERENCE BETWEEN THE TWO. IT IS LIKE SAYING: THE DIFFERENCE BETWEEN JACK AND JILL IS THAT BOBBY LIKES TO FETCH PAILS OF WATER. SO WHAT IF PLASMA CELLS SECRETE IgE? THERE IS NO SEMANTIC LINK WITH THIS CONCEPT TO EITHER NORMAL IMMUNE RESPONSES AND TYPE I HYPERSENSITIVITY REACTIONS - SO WE'RE LEFT GUESSING WHICH DOES WHAT AND THAT (PROBABLY) THE REMAINING ONE THEN DOES NOT. WHILE I COULD ATTEMPT TO FIX THE SENTENCE, I AM NOT QUITE SURE OF THE ANSWER AND DON'T WANT TO GUESS. —Preceding unsigned comment added by 76.87.162.135 (talk) 04:35, 11 March 2008 (UTC)
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[edit] Type 5?
i was to believe that an immune response that targetted the bodies own tissues was an autoimmune disease, not neccesarily a hypersensitivity reaction. perhaps it should be clearer what the relationship between the two are? —Preceding unsigned comment added by Chaotic rach (talk • contribs)
- Would you please cite the text that is confusing?Niels Olson 00:45, 19 April 2007 (UTC)
- It's the strange Type 5 text. The questioner is right: Myasthenia gravis and Graves Disease are B-cell mediated autoimmune diseases. An "allergy" (as the term is used by the average person) requires a non-self component for the antigen. WhatamIdoing 01:39, 7 June 2007 (UTC)
- Unfortunately, the colloquial use of allergy simplifies a more complex immunological reality. An "allergy" to peanuts, for instance, is mediated by a Type I hypersensitivity mechanism, whereas an "allergy" to nickel (for example in less expensive jewelry) is a delayed-type hypersensitivity (type IV). To answer the original questioner, these hypersensitivity reactions are the mechanisms by which some autoimmune diseases cause damage. In Myasthenia gravis and Graves Disease, antibodies are produced to the acetylcholine receptor and the thyroid stimulating hormone receptor respectively. Unlike most Type II hypersensitivities, these diseases don't cause the death of the cells, rather depletion of the receptor (in MG) or activation of the receptor (in Graves). Thus, they are sometimes classified as type V, to acknowledge the fact that they do not cause the death of cells via ADCC. This being the case, can you suggest any changes that might help to clarify the article? Jprawn 20:34, 9 June 2007 (UTC)
[edit] Is farmer's lung really a type II hypersensitivity?
It was my understanding that farmer's lung (hypersensitivity pneumonitis) was classically thought to be a type III hypersensitivity, although more recent research (Allergy Asthma Proc. 2007 Jan-Feb;28(1):25-7) has shown type IV hypersensitivity as having an important role. Should the link to farmer's lung be moved down to either type III or type IV? Jprawn 19:16, 17 May 2007 (UTC)
[edit] type 2 cytotoxic vs noncytotoxic
I thought there is a distinction btwn type 2 cytotoxic and noncytotoxic. Please confirm. —Preceding unsigned comment added by Tkjazzer (talk • contribs) 20:55, 11 November 2007 (UTC)
[edit] Type 3 - immune complex
Shouldn't Fibromyaliga be listed under this type? I know there is still a lot that is unknown about Fibromyalgia, but it seems this would be the appropriate category to list it as it does cause hypersensitivity to temperature and touch. Angelmunchkin04 (talk) 19:05, 22 January 2008 (UTC)
