Talk:Hyperplasia

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[edit] I

I think it is missleading to state the hyperplasia may be caused by neoplasia because the two processes are fundamentally (and clinically) very different.

A hyperplasia arrises when cells in a certain tissue start responding to an external stimulus (mitogenic signal) to grow. This can occur in normal physiology (e.g. breast enlargement during pregnancy) or pathologically (e.g. enlarged prostate).

A neoplasia arrises when a cell suddenly starts dividing irrespective of mitogenic stimulus. This is invariably a pathological process, although the degree of "harm" caused will depend on factors such as where the neoplasia is located, or whether is is benign (i.e. non invassive) or malignant (i.e. invassive).

Thus, hyperplasia and neoplasia are different at a molecular levels (hyperplasia = inappropriate or unusual expression of growth receptor; neoplasia = mutation leading to growth irrespective of external signals) and clinically (a hyperplasia will stop growing the moment the signal stops; a neoplasia will not stop growingmake the requested changes. -Rustavo^{Talk/Contribs} 02:45, 26 May 2007 (UTC)