Hydroxylysine kinase

From Wikipedia, the free encyclopedia

In enzymology, a hydroxylysine kinase (EC 2.7.1.81) is an enzyme that catalyzes the chemical reaction

GTP + 5-hydroxy-L-lysine GDP + 5-phosphonooxy-L-lysine

Thus, the two substrates of this enzyme are GTP and 5-hydroxy-L-lysine, whereas its two products are GDP and 5-phosphonooxy-L-lysine.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is GTP:5-hydroxy-L-lysine O-phosphotransferase. Other names in common use include hydroxylysine kinase (phosphorylating), and guanosine triphosphate:5-hydroxy-L-lysine O-phosphotransferase. This enzyme participates in lysine degradation.

[edit] References

• IUBMB entry for 2.7.1.81
• BRENDA references for 2.7.1.81 (Recommended.)
• PubMed references for 2.7.1.81
• PubMed Central references for 2.7.1.81
• Google Scholar references for 2.7.1.81
• Hiles RA, Henderson LM (1972). "The partial purification and properties of hydroxylysine kinase from rat liver". J. Biol. Chem. 247: 646–51. PMID 4621658. 

[edit] External links

The CAS registry number for this enzyme class is 9073-58-9.

• IUBMB entry for 2.7.1.81

• KEGG entry for 2.7.1.81

• BRENDA entry for 2.7.1.81

• NiceZyme view of 2.7.1.81

• EC2PDB: PDB structures for 2.7.1.81

• PRIAM entry for 2.7.1.81

• PUMA2 entry for 2.7.1.81

• IntEnz: Integrated Enzyme entry for 2.7.1.81

• MetaCyc entry for 2.7.1.81

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047992: hydroxylysine kinase

• AMIGO entry for GO code 0047992: hydroxylysine kinase