Hydroxycyclohexanecarboxylate dehydrogenase

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In enzymology, a hydroxycyclohexanecarboxylate dehydrogenase (EC 1.1.1.166) is an enzyme that catalyzes the chemical reaction

(1S,3R,4S)-3,4-dihydroxycyclohexane-1-carboxylate + NAD⁺ $\rightleftharpoons$ (1S,4S)-4-hydroxy-3-oxocyclohexane-1-carboxylate + NADH + H⁺

Thus, the two substrates of this enzyme are (1S,3R,4S)-3,4-dihydroxycyclohexane-1-carboxylate and NAD⁺, whereas its 3 products are (1S,4S)-4-hydroxy-3-oxocyclohexane-1-carboxylate, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (1S,3R,4S)-3,4-dihydroxycyclohexane-1-carboxylate:NAD+ 3-oxidoreductase. Other names in common use include dihydroxycyclohexanecarboxylate dehydrogenase, and (-)t-3,t-4-dihydroxycyclohexane-c-1-carboxylate-NAD+ oxidoreductase.

[edit] References

IUBMB entry for 1.1.1.166
BRENDA references for 1.1.1.166 (Recommended.)
PubMed references for 1.1.1.166
PubMed Central references for 1.1.1.166
Google Scholar references for 1.1.1.166
Whiting GC, Coggins RA (1974). "A new nicotinamide-adenine dinucleotide-dependent hydroaromatic dehydrogenase of Lactobacillus plantarum and its role in formation of (minus)t-3,t-4-dihydroxycyclohexane-c-1-carboxylate". Biochem. J. 141: 35–42. PMID 4375976.