Talk:Hyaluronan

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[edit] Use as a dietary supplement

I saw hyaluronic acid in 20mg capsules available as a dietary supplement at a health food store recently. However, the label on the bottle made no claims. What are the purported benefits of oral hyaluronic acid supplementation? Have any studies been conducted on this? --LostLeviathan 15:33, 31 August 2005 (UTC)

There are no benefits to oral hyaluronic acid. If one were to ingest hyaluronic acid it would be completely degraded in the acidic conditions of the stomach. The degradation products would likely continue through the digestive tract and be excreted. There is absolutely no way that oral hyaluronic acid would ever wind up in arthritic joints.--Herb West 14:58, 16 September 2005 (UTC)

I saw this claim: "Hyaluronic acid extracted from rooster combs has too large a chemical size for absorption by the intestinal tract. When directly extracted from rooster combs, the molecular weight is 1.2 to 1.5 million Daltons (Da).2 For comparison, the average molecule weight of an amino acid is approximately 110 Da. But, wouldn’t you know it, Japanese scientists developed a proprietary enzyme-cleaving technique to lower the molecular weight of hyaluronic acid without altering its chemical nature. The final molecular weight of hyaluronic acid processed by the Injuv™ process is 5,000 Daltons. This allows hyaluronic acid to be taken orally as a nutritional supplement and absorbed in the intestinal tract.

Subsequent research has proven the absorption of oral delivery of Hyaluronic acid and then its ability to be taken up by joints. The results of this study, which examined the absorption, excretion and distribution of radiolabeled hyaluronic acid after a single oral administration in Wistar rats and Beagle dogs, demonstrated that HA is absorbed and distributed to organs and joints after a single oral administration. "

the site was http://www.rejuvenation-science.com/hylauronic-acid.html this gives more info: http://www.rejuvenation-science.com/n_hyaluronic_acid-oral.html

Does this makes sense? - Nick

Nick, the study mentioned in those pages doesn't seem to've been published anywhere as I can't find it indexed in Medline. I wouldn't use it as a source. Emp² 16:29, 17 June 2006 (UTC)

[edit] References

I noticed that the HTML links were not cited at the end of the article. I'm fairly new to this and have been using footnotes "ref" -style to cite. I changed to this method from ignorance of how to cite HTML otherwise - sorry if I've offended a previous editor.Lystrablue 05:22, 26 December 2006 (UTC)

[edit] Structure of Hyaluronan

The current image of the hyaluronan structure on this page is incorrect. Hyaluronic acid is a repeating disaccharide with the following structure: GlcNAc(beta1-->4)GlcA(beta1-->3)

The current image of the hyaluronan is not according to this structure.

Source: Nomenclature of glycoproteins, glycopeptides and peptidoglycans, IUPAC-IUB Joint Commission on Biochemical Nomenclature (JCBN)

http://www.chem.qmul.ac.uk/iupac/misc/glycp.html Dabalk 16:07, 8 April 2007 (UTC)Dabalk


You're right. It is wrong. Good catch. --Herb West 03:30, 27 December 2006 (UTC)
It's now corrected. --Ed (Edgar181) 19:55, 19 July 2007 (UTC)

[edit] Does anyone know?

In using HA for horses, I have noticed that there are 2 different types used on the lables. I am wondering what the differences are, and what the difference might be to how the 2 different types might be utilized by the animal? One is Hyaluronic acid, and the other is Sodium Haluronate. 63.152.3.34 04:33, 16 March 2007 (UTC)

[edit] Everyone is so vague

I have searched the internet looking for REAL answers as to exactly how HA is made for these injections or oral supplements but nothing is out there. You have to read between the lines to figure out it is made from chickens, birds and have heard in some cases, human fetuses. Is there any truth to the last part of this and does anyone have a REAL answer to the following question? "What, exactly, is Hyaluronic Acid or Sodium Hyaluronic Acid made from when produced for oral supplements or injections into joints or even produced for Restylane injections, which are supposedly pure SHA?" 24.238.226.95 07:54, 11 April 2007 (UTC)S Vaughan

From my understanding some companies get it from chicken combs and some make it through bacterial fermtation. The fetuses thing is totally bunk. Remember 14:03, 26 April 2007 (UTC)

[edit] Cosmetic Applications

In the cosmetic section, the article seems to imply that there are contra-indications for people on 'blood mediation'. Does anyone know what this might mean? (It doesn't seem to be specific enough to make sense. Ie, blood thinners, or blood products (ie platelets)...?). If no one knows I'll look this up when I have time. bfigura (talk) 05:07, 17 August 2007 (UTC)

Removed. I can find no studies confirming this, and neither can the FDA. [1] Feezo (Talk) 05:48, 17 August 2007 (UTC)