Homatropine
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Homatropine
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| Systematic (IUPAC) name | |
| (N,N-dimethyl-8-azoniabicyclo[3.2.1]oct-3-yl) 2-hydroxy-2-phenyl-acetate bromide | |
| Identifiers | |
| CAS number | |
| ATC code | A02 S01FA05 |
| PubChem | |
| DrugBank | |
| Chemical data | |
| Formula | C16H22BrNO3 |
| Mol. mass | 356.26 g/mol |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | ? |
| Half life | ? |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
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| Legal status | |
| Routes | ? |
Homatropine (Equipin, Isopto Homatropine) is an anticholinergic medication that inhibits muscarinic acetylcholine receptors and thus the parasympathetic nervous system. It is used in eye drops as a cycloplegic, to temporarily paralyze accommodation, and as a mydriatic, to dilate the pupil.
Homatropine is less potent than atropine and has a shorter duration of action. It is available as the hydrobromide or methylbromide salt.
Certain preparations of drugs such as hydrocodone are mixed with a small, sub-theraputic amount homatropine methylbromide to discourage intentional overdose. [1]
Homatropine is also given as an atropine substitute given to reverse the muscarinic and CNS effects associated with indirect cholinomimetic (anti-AChase) administration.
[edit] Side effects
- Blurred vision
- Sensitivity to light
[edit] Contraindications
- Untreated glaucoma
- Myasthenia gravis
- Severe heart failure
- Thyrotoxicosis
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