HLA-B8

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major histocompatibility complex (human), class I, B8
Alleles B*0801
Structure (See HLA-B)
Symbol(s) HLA-B
EBI-HLA B*0801
Locus chr.6 6p21.31

HLA-B8 (B8) is an HLA-B serotype. The serotype identifies the HLA-B*08 gene products.[1] (For terminology help see: HLA-serotype tutorial) HLA-B8, previously known as HL-A8 was one of the first identified of the HLA antigens. It coined the "Super B8" haplotype, also called the ancestral European haplotype because of its common occurrence in Europe, particular the isles and Scandinavia.


[edit] Serotype

B08 serotype recognition of Some HLA B*08 allele-group gene products[2]
B*08 B8 Sample
allele  %  % size (N)
0801 99 6508


[edit] Alleles

HLA B*0801 frequencies
freq
ref. Population (%)
[3] Ireland South 18.2
[3] Australia New South Wales 17.3
[3] Ireland Northern 16.2
[3] Belgium 12.6
[3] Oman 11.0
[3] Spain Basque Gipuzkoa Province 9.1
[3] Finland 8.9
[3] France South East 8.9
[3] Scotland Orkney 8.8
[3] Morocco Nador Metalsa Class I 8.7
[3] India New Delhi 8.3
[3] Spain Eastern Andalusia Gipsy 8.1
[3] Madeira 7.8
[3] Guinea Bissau 7.7
[3] Iran Baloch 7.6
[3] South Africian Natal Zulu 7.5
[3] Brazil Belo Horizonte 7.4
[3] Cape Verde Southeastern Islands 7.3
[3] Romanian 7.3
[3] Saudi Arabia Guraiat and Hail 7.1
[3] South Africa Natal Tamil 7.1
[3] Georgia Svaneti Svans 6.9
[3] India Andhra Pradesh Golla 6.7
[3] Portugal North 6.5
[3] Azores Santa Maria and Sao Miguel 6.4
[3] Uganda Kampala 6.2
[3] Cape Verde Northwestern Islands 5.6
[3] Cameroon Yaounde 5.4
[3] Italy Bergamo 5.3
[3] Czech Republic 5.2
[3] Cameroon Pygmy Baka 5.0
[3] Senegal Niokholo Mandenka 4.8
[3] Kenya Nandi 4.6
[3] Spain Catalonia Girona 4.6
[3] Tunisia 4.6
[3] Bulgaria Gipsy 4.5
[3] Tunisia Tunis 4.5
[3] Brazil 4.3
[3] Portugal Centre 4.0
[3] Sudanese 4.0
[3] Cameroon Sawa 3.8
[3] Jordan Amman 3.8
[3] Australian Aborigine Cape York Peninsula 3.5
[3] Georgia Tibilisi Kurds 3.4
[3] Zambia Lusaka 3.4
[3] Kenya 3.1
[3] Zimbabwe Harare Shona 3.1
[3] Kenya Luo 3.0
[3] Mexico Zaptotec Oaxaca 3.0
[3] India North Hindus 2.9
[3] Mexico Mestizos 2.4
[3] Ivory Coast Akan Adiopodoume 2.3
[3] Australian Aborigine Groote Eylandt 2.0
[3] Portugal South 2.0
[3] Georgia Tibilisi Georgians 1.9
[3] Azores Central Islands 1.8
[3] Bulgaria 1.8
[3] Argentina Toba Rosario 1.7
[3] Croatia 1.7
[3] India North Delhi 1.6
[3] China North Han 1.4
[3] Cameroon Beti 1.1
[3] Cameroon Bakola Pygmy 1.0
[3] India West Coast Parsis 1.0
[3] Taiwan Siraya 1.0

[edit] References

  1. ^ Marsh SG, Albert ED, Bodmer WF, et al (2005). "Nomenclature for factors of the HLA system, 2004". Tissue Antigens 65 (4): 301–69. doi:10.1111/j.1399-0039.2005.00379.x. PMID 15787720. 
  2. ^ derived from IMGT/HLA
  3. ^ a b c d e f g h i j k l m n o p q r s t u v w x y z aa ab ac ad ae af ag ah ai aj ak al am an ao ap aq ar as at au av aw ax ay az ba bb bc bd be bf bg bh bi bj bk bl bm Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database: http://www.allelefrequencies.net". Tissue Antigens 61 (5): 403-7. PMID 12753660. 
v • d • e
HLA-B serotypes and allele groups

HLA-B · B5 (B51 · B52) · B7 · B8 · B12 (B44 · B45) · B13 · B14 (B64 · B65) · B15 (B62 · B63 · B70 · B71 · B75 · B76 · B77) · B16 (B38 · B39) · B17 (B57 · B58) · B18 · B21 (B49 · B50) · B22 (B54 · B55 · B56) · B27 · B35 · B37 · B40 (B60 · B61) · B41 · B42 · B46 · B47 · B48 · B53 · B59 · B67 · B73 · B78 · B81 · B*82 · B*83