Hering-Breuer reflex
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The Hering-Breuer reflex, named for Josef Breuer and Ewald Hering[1][2][3], is a reflex triggered to prevent overinflation of the lungs. Pulmonary stretch receptors present in the smooth muscle of the airways respond to excessive stretching of the lung during large inspirations.
Once activated, they send action potentials through large myelinated fibers[4] of the paired vagus nerves to the apneustic center of the pons, inhibiting the inspiratory neurons present there. This inhibits inspiration, allowing expiration to occur.[5]
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[edit] History
Josef Breuer and Ewald Hering reported in 1868 that a maintained distention of the lungs of anesthetized animals decreased the frequency of the inspiratory effort or caused a transient apnea. The stimulus being pulmonary inflation.
[edit] Anatomy and physiology
The neural circuit that controls the Hering-Breuer reflex involves several regions of the central nervous system, and both sensory and motor components of the vagus nerve. Increased sensory activity of the pulmonary-stretch lung afferents (via the vagus nerve) results in inhibition of the central inspiratory drive and thus inhibition of inspiration and initiation of expiration. The lung afferents also send inhibitory projections to the cardiac vagal motor neurones (CVM) in the nucleus ambiguus (NA) and dorsal motor vagal nucleus (DMVN). The CVMs, which send motor fibers to the heart via the vagus nerve, are responsible for tonic inhibitory control of heart rate. Thus, an increase in pulmonary stretch receptor activity leads to inhibition of the CVMs and an elevation of heart rate (tachycardia). This is a normal occurrence in healthy individuals and is known as sinus arrhythmia.
[edit] Rate and depth of breathing
Early physiologists believed the reflex played a major role in establishing the rate and depth of breathing in humans.[4] While this may be true for most animals, it is not the case for most adult humans at rest.[4] However, the reflex may determine breathing rate and depth in newborns and in adult human when tidal volume is more than 1 L, as when exercising.[4]
[edit] References
- ^ synd/3172 at Who Named It
- ^ K. E. K. Hering. Die Selbststeuerung der Athmung durch den Nervus vagus. Sitzungsberichte der kaiserlichen Akademie der Wissenschaften. Mathematisch–naturwissenschaftliche Classe, Wien, 1868, 57 Band, II. Abtheilung: 672-677.
- ^ Josef Breuer. Die Selbststeuerung der Athmung durch den Nervus vagus. Sitzungsberichte der kaiserlichen Akademie der Wissenschaften. Mathematisch–naturwissenschaftliche Classe, Wien, 1868, 58 Band, II. Abtheilung: 909-937.
- ^ a b c d West, John F. (2005). Respiratory physiology: the essentials. Hagerstwon, MD: Lippincott Williams & Wilkins, pp127-8. ISBN 0-7817-5152-7.
- ^ Sherwood, Lauralee (2001). "Ch 13", Human physiology: from cells to systems. Pacific Grove, CA: Brooks/Cole. ISBN 0534568262.
[edit] External links
- Physiology at MCG 4/4ch6/s4ch6_15
- Hering-Breuer+reflex at eMedicine Dictionary
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