Glyoxylate reductase

From Wikipedia, the free encyclopedia

In enzymology, a glyoxylate reductase (EC 1.1.1.26) is an enzyme that catalyzes the chemical reaction

glycolate + NAD⁺ $\rightleftharpoons$ glyoxylate + NADH + H⁺

Thus, the two substrates of this enzyme are glycolate and NAD⁺, whereas its 3 products are glyoxylate, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is glycolate:NAD+ oxidoreductase. Other names in common use include NADH-glyoxylate reductase, glyoxylic acid reductase, and NADH-dependent glyoxylate reductase. This enzyme participates in glyoxylate and dicarboxylate metabolism.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 2DBQ, 2DBR, and 2DBZ.

[edit] References

IUBMB entry for 1.1.1.26
BRENDA references for 1.1.1.26 (Recommended.)
PubMed references for 1.1.1.26
PubMed Central references for 1.1.1.26
Google Scholar references for 1.1.1.26
Zelitch I (1953). "Oxidation and reduction of glycolic and glyoxylic acids in plants II. Glyoxylic acid reductase". J. Biol. Chem. 201: 719–726.
Zelitch I (1955). "The isolation and action of crystalline glyoxylic acid reductase from tobacco leaves". J. Biol. Chem. 216: 553–575.